Abstract An expedient one-pot sequential five component synthesis of highly substituted pyrazolo-N-methyl-piperidine grafted spiro-indenoquinoxaline pyrrolidine heterocycles involving [3 + 2]-cycloaddition of azomethine ylides as the key step is described. The protocol provides a mild reaction condition, high yield of the products, high regioselectivity and operational simplicity to assemble complex structural entity in a single operation. The structure of the product was confirmed by spectroscopic techniques and elemental analysis. Graphical Abstract

中文翻译：

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一个简单的原子——通过顺序多组分反应经济合成高度取代的吡唑并-N-甲基-哌啶接枝的螺-茚并喹喔啉吡咯烷杂环

摘要 描述了高度取代的吡唑并-N-甲基-哌啶接枝的螺-茚并喹喔啉吡咯烷杂环的方便的一锅序贯五组分合成，涉及作为关键步骤的偶氮甲碱叶立德的[3 + 2]-环加成。该协议提供了温和的反应条件、产品的高产率、高区域选择性和操作简单性，可在一次操作中组装复杂的结构实体。通过光谱技术和元素分析确认了产物的结构。图形概要