ABSTRACT

Background: Hyperbaric oxygen (HBO₂) is currently emerging as a promising therapeutic option for diseases involving impaired tissue repair and remodeling. In this regard, HBO₂ has been shown to modulate signaling pathways responsible for matrix metalloproteinases (MMPs) regulation, which makes the MMPs interesting targets for investigation. However, the understanding regarding how HBO₂ treatment affects the expression and activity of the MMP family members in different tissues and diseases needs to be clarified. The precise roles of MMPs in the physiopathology of various tissue repair disorders also remain unclear. Because of potential off-target systemic effects of the HBO₂ on MMPs, researchers and physicians should carefully consider whether their patients could be affected adversely by HBO₂ exposure. Aims: This narrative review provides an overview of MMP biology (structure, function, and regulation) and summarizes available data showing how MMPs respond to HBO₂ in different tissues and pathologies, also highlighting possible mechanisms.

摘要

背景：高压氧（HBO ₂）目前正在成为一种有前途的治疗选择，用于治疗涉及组织修复和重塑受损的疾病。在这方面，HBO ₂已被证明可以调节负责基质金属蛋白酶 (MMP) 调节的信号通路，这使得 MMP 成为研究的有趣目标。然而，关于 HBO ₂治疗如何影响 MMP 家族成员在不同组织和疾病中的表达和活性的理解需要澄清。MMPs 在各种组织修复疾病的病理生理学中的确切作用也仍不清楚。_{由于 HBO 2}的潜在脱靶系统性影响关于 MMP，研究人员和医生应该仔细考虑他们的患者是否会受到 HBO ₂暴露的不利影响。目的：这篇叙述性综述提供了 MMP 生物学（结构、功能和调节）的概述，并总结了显示 MMP 如何在不同组织和病理中对 HBO _{2作出反应的可用数据，同时强调了可能的机制。}