The purpose of the study was to investigate the expressions of VEGF and pAkt protein, and to evaluate their clinicopathological implications in oral cancer. A total of 55 cases of oral squamous cell carcinoma (OSCC) and 15 cases of inflammatory lesion as a control were included in the study. Expression pattern of pAkt and VEGF protein was evaluated through immunohistochemistry. In addition, apoptosis was evaluated using TUNEL assay. pAkt protein showed 43.63% expression in oral cancer, whereas undetectable expression was noticed in inflammatory lesion (p 0.05). High expression of VEGF (58.18%) was noticed in OSCC cases and inflammatory lesion did not show any expression. The expression pattern of VEGF increased with increasing the grade of tumour and difference in expression pattern among grades was statistically significant (p < 0.05). Moreover, VEGF protein expression was associated with stages of the cancer). The positive rate of apoptosis was 70.9%. The percentage of apoptotic cells varied from 0.3% to 20.3% and the median was 9.5. These findings advocate that overexpression of VEGF and upregulation of Akt may play a role in the development and progression of oral squamous cell carcinoma.

这项研究的目的是调查VEGF和pAkt蛋白的表达，并评估其在口腔癌中的临床病理意义。本研究共纳入55例口腔鳞状细胞癌（OSCC）和15例炎性病变作为对照。通过免疫组织化学评估pAkt和VEGF蛋白的表达模式。另外，使用TUNEL测定法评估凋亡。pAkt蛋白在口腔癌中显示43.63％的表达，而在炎症性病变中则检测不到表达（p 0.05）。在OSCC病例中发现VEGF的高表达（58.18％），炎性病变未显示任何表达。VEGF的表达模式随肿瘤等级的增加而增加，且不同级别之间的表达方式差异具有统计学意义（p <0.05）。此外，VEGF蛋白表达与癌症的分期有关。凋亡阳性率为70.9％。凋亡细胞的百分比从0.3％到20.3％不等，中位数为9.5。这些发现主张VEGF的过度表达和Akt的上调可能在口腔鳞状细胞癌的发生和发展中起作用。