ABSTRACT

Introduction

The tripartite motif (TRIM) plays various roles in pathological and physiological functions, including neurological diseases, genetic disorders, carcinogenesis, innate immune signaling, and antiviral activity. TRIM56 is a cytoplasmic protein whose expression is stimulated by type I interferon and may function as an antiviral agent. Here, the authors conducted a systematic search on papers that reported antiviral effects of TRIM56.

Areas covered

The authors conducted a comprehensive search of the PubMed database without time or language limitation, after using the Medical Subject Headings (MeSH) Database terms. Initially, a structured search and full article review yielded 31 papers. Relevant original and review articles on TRIM56 were included. The reference lists were then reviewed, and the cited articles were added. Expert opinion: TRIM56 has been shown to have direct antiviral actions against positive-sense single-stranded RNA viruses from the families Flaviviridae, Coronaviridae, and Retroviridae. Moreover, it may be effective against negative-sense single-strand RNA viruses from the families Paramyxoviridae and Orthomyxoviridae, as well as a DNA virus, Herpes simplex virus 1 (HSV-1). These studies could suggest the potential of a TRIM56-based antiviral against COVID-19 from the family Coronaviridae, containing single-stranded positive-sense RNA genome. However, its efficacy and antiviral mechanisms need to be further examined.

中文翻译：

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TRIM56抗病毒特性的系统评价：COVID-19的潜在治疗手段。

摘要

介绍

三方基序（TRIM）在病理和生理功能中扮演各种角色，包括神经系统疾病，遗传疾病，致癌作用，先天免疫信号传导和抗病毒活性。TRIM56是一种胞质蛋白，其表达受到I型干扰素的刺激，可能起抗病毒剂的作用。在这里，作者对报告TRIM56抗病毒作用的论文进行了系统的搜索。

覆盖区域

在使用医学主题词（MeSH）数据库术语后，作者对PubMed数据库进行了全面搜索，没有时间或语言限制。最初，结构化搜索和全文阅读产生了31篇论文。包含有关TRIM56的相关原始文章和评论文章。然后查阅参考文献清单，并添加引用的文章。专家意见：TRIM56已被证明对黄病毒科，冠状病毒科和逆转录病毒科的正向单链RNA病毒具有直接的抗病毒作用。此外，它可能有效对抗副粘病毒科和正粘病毒科的负义单链RNA病毒以及DNA病毒，即单纯疱疹病毒1（HSV-1）。这些研究可能表明基于TRIM56的抗CorV病毒科的COVID-19抗病毒药的潜力，该病毒含有单链正链RNA基因组。但是，其功效和抗病毒机制需要进一步检查。