ABSTRACT

Introduction

Niosomes have recently grabbed attention as one of the best tools for various site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants (nonionic; tweens and spans) of different HLB values and cholesterol are the fundamental components for these formulations. It is an alternative controlled ocular drug delivery system to liposomes to overcome the problems associated with sterilization, large-scale production, and stability. It also enhances the adhesion or retention ability of drug at the ocular site. Hydrophilic or lipophilic or amphoteric drugs can be easily encapsulated in niosomes. Besides, niosomes are a leading vesicular system compatible with most of the drugs for site-specific delivery.

Areas covered

This article reveals challenges and barriers for ocular drug delivery, various transporters and receptors present in the ocular region for the transportation of therapeutics as well as nutrients, and various method of preparations, loading methods and application potential of niosomes in ocular drug delivery.

Expert opinion

Niosomes, a vesicular system offers numerous advantages and applicability because of its good stability, non-immunogenicity, permeation potential, and controlled release ability etc. This drug delivery system has been efficiently used in the treatment of many ocular diseases.

中文翻译：

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脂质体在眼部递送中的新兴潜力。

摘要

介绍

Niosomes最近作为各种特定位置的药物输送系统（包括眼科药物输送）的最佳工具之一而受到关注。具有不同HLB值和胆固醇的表面活性剂（非离子型；补间和跨度）是这些配方的基本成分。它是脂质体的替代性受控眼部药物递送系统，可克服与灭菌，大规模生产和稳定性相关的问题。它还增强了药物在眼部的粘附或保留能力。亲水性或亲脂性或两性药物可以很容易地包裹在脂质体中。此外，脂质体是领先的囊泡系统，与大多数用于特定部位递送的药物兼容。

覆盖区域

本文揭示了眼用药物输送的挑战和障碍，眼部区域中用于治疗药物和营养物输送的各种转运蛋白和受体，以及脂质体在眼用药物输送中的各种制备方法，负载方法和应用潜力。

专家意见

脂质体，一种囊泡系统，由于其良好的稳定性，非免疫原性，渗透潜能和控释能力等优点而具有许多优势和适用性。该药物递送系统已被有效地用于治疗许多眼部疾病。