The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal‐polyp disease. The study examined 62 nasal‐polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction‐restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal‐polyp patients (QQ = 69.35%, QR = 25.81%, RR = 4.83%) and healthy controls (QQ = 52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal‐polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.

中文翻译：

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土耳其人PON1基因和鼻息肉中的Q192R多态性。

鼻息肉的发病机理尚未完全了解。氧化损伤促进鼻粘膜中息肉的形成。对氧磷酶1（PON1）酶是一种重要的肝酶，具有很高的抗氧化活性。在这项研究中，我们调查了PON1酶Q192R基因型多态性与鼻息肉病之间的相关性。该研究检查了62名鼻息肉患者和88名对照。使用聚合酶链反应-限制性片段长度多态性确定PON1 Q192R多态性。鼻息肉患者（QQ = 69.35％，QR = 25.81％，RR = 4.83％）和健康对照组（QQ = 52.27％，QR = 44.31％，RR = 3.40％）PON1基因的基因型分布有显着差异。我们的研究结果表明PON1 QQ基因型（比值比[OR] = 2.066，P = .036）与发生鼻息肉疾病的风险较高相关，而QR基因型（OR = 0.437，P  = .021）显示的风险较低。