Anisotropic Bimetallic Core-Satellite-Poly(aniline) Nanohybrids for Detection of Autoantibodies.,Macromolecular Rapid Communications

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Anisotropic Bimetallic Core-Satellite-Poly(aniline) Nanohybrids for Detection of Autoantibodies.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-09-09 , DOI: 10.1002/marc.202000331
Eun Young Hwang ₁ , Jae Hee Lee ₁ , Dong Woo Lim ₁

Affiliation

Bimetallic core–satellite nanoparticles are widely exploited in surface‐enhanced Raman scattering (SERS)‐based applications due to their enhanced optical properties compared to single‐component metallic nanoparticles (MNPs). In addition, anisotropic hybrid nanostructures containing both MNPs and polymeric compartments constitute a new class of functional nanomaterials for photonic applications because they show different functionalities and physicochemical characteristics at two distinct compartments. Herein, synthesis of two kinds of anisotropic bimetallic core–satellite–poly(aniline) nanohybrids (ABCPNs) using small or polymeric ligand‐coated gold nanospheres or gold nanorods as seeds is reported. The ABCPNs exhibit enhanced optical properties due to a local electromagnetic field generated in the narrow interparticle gap between core and satellite nanoparticles. Furthermore, a SERS‐based quantitative analysis of autoantibodies against cyclic citrullinated peptide using the ABCPNs as SERS nanoprobes for a diagnosis of early rheumatoid arthritis is demonstrated, suggesting that these multifunctional nanostructures will be potential for advanced SERS‐based biosensors.

中文翻译：

用于检测自身抗体的各向异性双金属核-卫星-聚（苯胺）纳米杂交体。

双金属核-卫星纳米颗粒由于具有比单组分金属纳米颗粒（MNP）更高的光学性能，因此在基于表面增强拉曼散射（SERS）的应用中得到了广泛利用。此外，同时包含MNP和聚合物隔室的各向异性杂化纳米结构构成了用于光子应用的一类功能纳米材料，因为它们在两个不同的隔室中显示出不同的功能和理化特性。本文报道了使用小或聚合物配体包被的金纳米球或金纳米棒作为种子合成两种各向异性的双金属核-卫星-聚苯胺纳米杂化物（ABCPN）的方法。由于在核心和卫星纳米粒子之间的狭窄粒子间间隙中产生了局部电磁场，因此ABCPNs显示出增强的光学性能。此外，还证明了使用ABCPNs作为SERS纳米探针对环瓜氨酸肽的自身抗体进行基于SERS的定量分析，以诊断早期类风湿性关节炎，这表明这些多功能纳米结构对于基于SERS的先进生物传感器将具有潜力。

更新日期：2020-10-19

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