Guest-Reaction Driven Cage to Conjoined Twin-Cage Mitosis-Like Host Transformation.,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Guest-Reaction Driven Cage to Conjoined Twin-Cage Mitosis-Like Host Transformation.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-09 , DOI: 10.1002/anie.202011474
Pei-Ming Cheng _{1,

2} , Li-Xuan Cai ₁ , Shao-Chuan Li _{1,

3} , Shao-Jun Hu _{1,

3} , Dan-Ni Yan _{1,

3} , Li-Peng Zhou ₁ , Qing-Fu Sun _{1,

3}

Affiliation

We report here a guest‐reaction‐induced mitosis‐like host transformation from a known Pd₄L₂ cage 1 to a conjoined Pd₆L₃ twin‐cage 2 featuring two separate cavities. The encapsulation of 1‐hydroxymethyl‐2‐naphthol (G1), a known ortho‐quinone methide (o‐QMs) precursor, within the hydrophobic cavity of cage 1 is found crucial to realize the cage to twin‐cage conversion. Confined G1 molecules within the nanocavity undergo self‐coupling dimerization reaction to form 2,2′‐dihydroxy‐1,1′‐dinaphthylmethane (G2) which then triggers the cage to twin‐cage mitosis. The same conversion also proceeds, in a much faster rate, via the direct templation of G2, confirming the induced‐fit transformation mechanism. The structure of the (G2)₂⊂2 host–guest complex has been established by X‐ray crystallographic study, where cis‐ to trans‐ conformational switch on one bridging ligand is revealed.

中文翻译：

来宾反应驱动的笼子转为连体的双笼有丝分裂样宿主转化。

我们在这里报告客体反应诱导的有丝分裂样宿主转化，从已知的Pd ₄ L ₂笼1到具有两个独立腔的连体Pd ₆ L ₃双笼2。发现笼子1的疏水腔中1-羟甲基-2-萘酚（G1）（一种已知的邻醌甲基化物（o-QMs）前体）的包封对于实现笼子到双笼的转化至关重要。纳米腔体内的受限G1分子经历自偶联二聚化反应以形成2,2'-二羟基-1,1'-二萘基甲烷（G2），然后触发笼子进入双笼有丝分裂。通过G2的直接模板化，同样的转换也以更快的速度进行，从而确认了诱导拟合转换机制。（的结构G2）₂ ⊂ 2主-客体复合物已通过X射线晶体学研究，其中顺式-反式-对构象上的一个桥联配体开关显露建立。

更新日期：2020-09-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11