In article number 2001374, James L. Hedrick, Yi Yan Yang, and co‐workers show that guanidiniumfunctionalized polycarbonates reverse the antibiotic resistance phenotype, and improve antibiotic potency via intracellular protein precipitation, gene binding and subsequent reactive oxygen species generation. Importantly, the polymer allows for the effective repositioning of rifampicin and auranofin meant for Gram‐positive bacteria and arthritis, respectively, to be highly effective against multidrugresistant Gram‐negative bacteria both in vitro and in vivo.

中文翻译：

---

抗生素抗药性：大分子逆转抗生素抗药性表型并将药物重新用作有效的抗生素（Adv。Sci。17/2020）

James L. Hedrick，Yi Yan Yang和同事在文章编号2001374中显示，胍基官能化的聚碳酸酯可逆转抗生素抗性表型，并通过细胞内蛋白质沉淀，基因结合和随后的活性氧生成而提高抗生素效价。重要的是，该聚合物可以分别有效地重新定位分别用于革兰氏阳性细菌和关节炎的利福平和金诺芬，从而在体内和体外对多药耐药革兰氏阴性细菌具有很高的抵抗力。