Expandable Polymer Assisted Wearable Personalized Medicinal Platform,Advanced Materials Technologies

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Expandable Polymer Assisted Wearable Personalized Medicinal Platform
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2020-09-09 , DOI: 10.1002/admt.202000411
Wedyan Babatain _{1,

2} , Abdurrahman Gumus _{1,

3} , Irmandy Wicaksono _{1,

4} , Ulrich Buttner _{1,

2} , Nazek El‐atab _{1,

2} , Mutee Ur Rehman ₁ , Nadeem Qaiser _{1,

2} , David Conchouso _{1,

2} , Muhammad Mustafa Hussain _{1,

2,

5}

Affiliation

Conventional healthcare, thoughts of treatment, and practice of medicine largely rely on the traditional concept of one size fits all. Personalized medicine is an emerging therapeutic approach that aims to develop a therapeutic technique that provides tailor‐made therapy based on everyone’s individual needs by delivering the right drug at the right time with the right amount of dosage. Advancement in technologies such as wearable biosensors, point‐of‐care diagnostics, microfluidics, and artificial intelligence can enable the realization of effective personalized therapy. However, currently, there is a lack of a personalized minimally invasive wearable closed‐loop drug delivery system that is continuous, automated, conformal to the skin, and cost‐effective. Here, design, fabrication, optimization, and application of a personalized medicinal platform augmented with flexible biosensors, heaters, expandable actuator and processing units powered by a lightweight battery are shown. The platform provides precise drug delivery and preparation with spatiotemporal control over the administered dose as a response to real‐time physiological changes of the individual. The system is conformal to the skin, and the drug is transdermally administered through an integrated microneedle. The developed platform is fabricated using rapid, cost‐effective techniques that are independent of advanced microfabrication facilities to expand its applications to low‐resource environments.

中文翻译：

可扩展聚合物辅助可穿戴个性化医疗平台

常规医疗保健，治疗思想和医学实践在很大程度上取决于适合所有人的传统观念。个性化医学是一种新兴的治疗方法，旨在开发一种治疗技术，该技术可通过在正确的时间以正确的剂量提供正确的药物，根据每个人的个人需求提供量身定制的治疗方法。可穿戴生物传感器，即时诊断，微流控技术和人工智能等技术的进步可以实现有效的个性化治疗。但是，目前缺乏一种连续，自动化，贴合皮肤且具有成本效益的个性化微创可穿戴闭环给药系统。在这里，设计，制造，优化，展示了个性化的医疗平台的应用，该平台上增加了由轻便电池供电的柔性生物传感器，加热器，可扩展的执行器和处理单元。该平台提供精确的药物输送和制备，并可以对给药剂量进行时空控制，以响应个体的实时生理变化。该系统与皮肤一致，并且该药物通过集成的微针经皮给药。开发的平台是使用快速，经济高效的技术制造的，该技术独立于先进的微制造设施，可将其应用扩展到资源匮乏的环境。该平台提供精确的药物输送和制备，并可以对给药剂量进行时空控制，以响应个体的实时生理变化。该系统适应皮肤，并且药物通过集成的微针经皮给药。开发的平台是使用快速，经济高效的技术制造的，该技术独立于先进的微细加工设备，以将其应用扩展到资源匮乏的环境。该平台提供精确的药物输送和制备，并可以对给药剂量进行时空控制，以响应个体的实时生理变化。该系统与皮肤一致，并且该药物通过集成的微针经皮给药。开发的平台是使用快速，经济高效的技术制造的，该技术独立于先进的微制造设施，可将其应用扩展到资源匮乏的环境。

更新日期：2020-10-12

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