Biodegradable Metal-Organic Framework-Based Microrobots (MOFBOTs).,Advanced Healthcare Materials

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Biodegradable Metal-Organic Framework-Based Microrobots (MOFBOTs).
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-09 , DOI: 10.1002/adhm.202001031
Anastasia Terzopoulou ₁ , Xiaopu Wang ₁ , Xiang-Zhong Chen ₁ , Mario Palacios-Corella ₂ , Carlos Pujante ₃ , Javier Herrero-Martín ₄ , Xiao-Hua Qin ₅ , Jordi Sort ₆ , Andrew J deMello ₃ , Bradley J Nelson ₁ , Josep Puigmartí-Luis _{7,

8} , Salvador Pané ₁

Affiliation

Microrobots and metal–organic frameworks (MOFs) have been identified as promising carriers for drug delivery applications. While clinical applications of microrobots are limited by their low drug loading efficiencies and the poor degradability of the materials used for their fabrication, MOFs lack motility and targeted drug delivery capabilities. The combination of these two fields marks the beginning of a new era; MOF‐based small‐scale robots (MOFBOTs) for biomedical applications. Yet, biodegradability is a major hurdle in the field of micro‐ and nanoswimmers including small‐scale robots. Here, a highly integrated MOFBOT that is able to realize magnetic locomotion, drug delivery, and selective degradation in cell cultures is reported for the first time. The MOF used in the investigations does not only allow a superior loading of chemotherapeutic drugs and their controlled release via a pH‐responsive degradation but it also enables the controlled locomotion of enzymatically biodegradable gelatin‐based helical microrobots under magnetic fields. The degradation of the integrated MOFBOT is observed after two weeks, when all its components fully degrade. Additionally, drug delivery studies performed in cancer cell cultures show reduced viability upon delivery of Doxorubicin within short time frames. This MOFBOT system opens new avenues for highly integrated fully biodegradable small‐scale robots.

中文翻译：

基于生物可降解金属有机框架的微型机器人（MOFBOT）。

微型机器人和金属有机框架（MOF）已被确定为药物输送应用中有希望的载体。尽管微型机器人的临床应用受到药物装载效率低和制造所用材料降解性差的限制，但MOF缺乏运动性和靶向药物传递能力。这两个领域的结合标志着新时代的开始。用于生物医学应用的基于MOF的小型机器人（MOFBOT）。然而，可生物降解性是包括小型机器人在内的微纳米洗涤器领域的主要障碍。在此，首次报道了高度集成的MOFBOT，它能够在细胞培养物中实现磁运动，药物传递和选择性降解。研究中使用的MOF不仅可以使化学治疗药物负载量更大，而且可以通过pH响应降解来控制释放，还可以使可酶降解的基于明胶的螺旋微型机器人在磁场下控制运动。两周后，当所有组件完全降解时，观察到集成的MOFBOT的降解。另外，在癌细胞培养物中进行的药物递送研究显示，在短时间内递送阿霉素后活力降低。这个MOFBOT系统为高度集成的，完全可生物降解的小型机器人开辟了新途径。两周后，当所有组件完全降解时，观察到集成的MOFBOT的降解。另外，在癌细胞培养物中进行的药物递送研究显示，在短时间内递送阿霉素后活力降低。这个MOFBOT系统为高度集成的，完全可生物降解的小型机器人开辟了新途径。两周后，当所有组件完全降解时，观察到集成的MOFBOT的降解。另外，在癌细胞培养物中进行的药物递送研究显示，在短时间内递送阿霉素后活力降低。这个MOFBOT系统为高度集成的，完全可生物降解的小型机器人开辟了新途径。

更新日期：2020-10-22

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