Intracellular Self-Assembly of Peptide Conjugates for Tumor Imaging and Therapy.,Advanced Healthcare Materials

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Intracellular Self-Assembly of Peptide Conjugates for Tumor Imaging and Therapy.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-09 , DOI: 10.1002/adhm.202001211
Yu Deng ₁ , Wenjun Zhan ₁ , Gaolin Liang ₁

Affiliation

Intracellular self‐assembly (ISA) is a versatile and powerful strategy for in situ constructing sophisticated and functional supramolecular nanostructures, which has been widely applied in biomedicine and biomedical engineering. Among the common building blocks for ISA, peptides have attracted increasingly attention due to their intrinsic bioactivity, biocompatibility, and biodegradability. Particularly, by conjugating functional motifs (e.g., probes or drugs) to peptides to yield the peptide conjugates, the latter show enhanced stability and efficiency, and probably new functions. In recent years, employing ISA of peptide conjugates for tumor imaging and treatment has achieved great progresses. Therefore, the recent progress of ISA of peptide conjugates is summarized in this progress report. Moreover, several examples of ISA of peptide conjugates for other important imaging or therapeutic applications are also introduced. Finally, a brief perspective on remaining challenges and potential directions for future research in this area is presented.

中文翻译：

肽的细胞内自组装结合物用于肿瘤成像和治疗。

细胞内自组装（ISA）是一种原位构建复杂且功能强大的超分子纳米结构的通用且强大的策略，已被广泛应用于生物医学和生物医学工程。在ISA的常见组成部分中，肽因其固有的生物活性，生物相容性和生物降解性而受到越来越多的关注。特别地，通过将功能性基序（例如，探针或药物）缀合至肽以产生肽缀合物，后者显示出增强的稳定性和效率，并且可能显示出新的功能。近年来，利用肽缀合物的ISA进行肿瘤成像和治疗取得了很大的进展。因此，该进展报告总结了肽缀合物的ISA的最新进展。此外，还介绍了用于其他重要成像或治疗应用的肽结合物ISA的几个示例。最后，简要介绍了该领域尚存的挑战和未来研究的潜在方向。

更新日期：2020-09-09

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