Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS). However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. In this study, a new polyethylene glycol hydrogel (PEG‐H) treatment model is developed to achieve sustained release of drugs at the locality while avoiding those adverse effects. The PEG‐H is composed of 4‐arm‐PEG‐SH and silver ions through a high affinity and dynamic reversible coordination bond between the thiol and silver ion. In the initial test, PEG‐H is loaded with Clarithromycin (CAM‐Lips@Hydrogel) or Clarithromycin and Budesonide liposomes (CAM+BUD‐Lips@Hydrogel). The results show that PEG‐H maintains the characteristics of self‐healing, biodegradability, moderate swelling rate, injectibility and sustained drug release. In in vivo studies, the hydrogel is injected into the maxillary sinus of ABRS rabbit models. In both a single or combined load, the hydrogel not only plays an effective role as an anti‐bacterial, but also inhibits inflammatory response of local sinus mucosa. In addition, no other side effects are observed in the ABRS rabbit model through behavioral observation and drug sensitivity tests. Therefore, the injectable self‐healing hydrogel with anti‐bacterial and anti‐inflammatory properties provides a new micro invasive therapeutic method for the clinical treatment of ABRS.

中文翻译：

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具有微生化治疗作用的急性细菌性鼻-鼻窦炎的具有抗菌和消炎作用的可注射和自愈水凝胶。

全身性抗生素治疗是急性细菌性鼻鼻窦炎（ABRS）的主要治疗方法。但是，这种治疗常常引起头晕，腹泻和耐药性的副作用。在这项研究中，开发了一种新的聚乙二醇水凝胶（PEG-H）治疗模型，以实现局部药物的持续释放，同时避免这些不利影响。PEG-H由4臂PEG-SH和银离子组成，通过巯基和银离子之间的高亲和力和动态可逆配位键形成。在初始测试中，PEG‐H装有克拉霉素（CAM–Lips @ Hydrogel）或克拉霉素和布地奈德脂质体（CAM + BUD–Lips @ Hydrogel）。结果表明，PEG-H保持自我修复，生物降解性，适度的溶胀率，可注射性和持续药物释放的特性。在体内研究中 将水凝胶注入ABRS兔模型的上颌窦。在单一或组合负荷下，水凝胶不仅起到抗菌作用，而且还抑制局部鼻窦黏膜的炎症反应。此外，通过行为观察和药物敏感性测试，在ABRS兔模型中未观察到其他副作用。因此，具有抗菌和消炎作用的可注射自愈水凝胶为ABRS的临床治疗提供了一种新的微创治疗方法。通过行为观察和药物敏感性测试，在ABRS兔模型中未观察到其他副作用。因此，具有抗菌和消炎作用的可注射自愈水凝胶为ABRS的临床治疗提供了一种新的微创治疗方法。通过行为观察和药物敏感性测试，在ABRS兔模型中未观察到其他副作用。因此，具有抗菌和消炎作用的可注射自愈水凝胶为ABRS的临床治疗提供了一种新的微创治疗方法。