NTCP deficiency causes gallbladder abnormalities in mouse and human.,Cellular and Molecular Gastroenterology and Hepatology

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NTCP deficiency causes gallbladder abnormalities in mouse and human.
Cellular and Molecular Gastroenterology and Hepatology ( IF 7.1 ) Pub Date : 2020-09-09 , DOI: 10.1016/j.jcmgh.2020.09.001
Fengfeng Mao ₁ , Meng-Xuan Wang ₂ , Xinfeng Hou ₃ , Zhongmin Zhou ₁ , Yan-Yan Yan ₄ , Ling-Juan Fang ₅ , Zexi Tan ₆ , Wei-Yuan Fang ₄ , Teng Liu ₄ , Wenhui He ₆ , Cong Li ₃ , Xin-Bao Xie ₄ , Shi-Qi Lu ₄ , Jianhua Sui ₇ , Fengchao Wang ₈ , Jun Han ₉ , Jian-She Wang ₄ , Wenhui Li ₈

Affiliation

School of Life Sciences, Beijing Normal University, Beijing, China; National Institute of Biological Sciences, Beijing, China.
Department of Pediatrics, Jinshan Hospital of Fudan University, Shanghai, China; The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
National Institute of Biological Sciences, Beijing, China; School of Life Sciences, Peking University, Beijing, China.
The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
Department of Pediatric Gastroenterology, the Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
National Institute of Biological Sciences, Beijing, China.
School of Life Sciences, Beijing Normal University, Beijing, China; National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
University of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.

We studied the pathological consequence of long-term hypercholanemia caused by NTCP deficiency, and found that NTCP deficiency leads to gallbladder abnormalities in both mice and humans, thereby pointing to a potentially underappreciated cause for gallbladder diseases encountered by physicians in the clinic.

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