In addition to standard anterior temporal lobectomy (ATL), subtemporal selective amygdalohippocampectomy (sSAH) is also a common technique for the treatment of medically intractable mesial temporal lobe epilepsy (MTLE). We conducted a systematic literature review to determine the seizure and neuropsychological outcomes in patients with MTLE who underwent sSAH. We searched PubMed and Embase using Medical Subject Headings and keywords related to sSAH, seizure outcome, and neuropsychological outcome. Titles, abstracts, and full-texts were screened in light of inclusion and exclusion criteria that were established a priori. Potential papers were reviewed by 3 reviewers, who reached a consensus on the final papers to be included. Literature review identified 208 abstracts from which a total of 29 full-text articles were reviewed. Six studies containing data from 4 countries (3 continents) met our inclusion criteria. The seizure-free rates at 12 months after sSAH ranged from 59.1% to 61.5% in 4 studies. Four studies showed that seizure-free rates ranged from 56% to 82.6% at 24 months after surgery. Six studies evaluated the neuropsychological changes of patients with MTLE after sSAH, including intelligence, verbal memory, nonverbal memory, language function, and so on. In terms of neuropsychological outcomes, there are some differences among the 6 studies. Taken together, sSAH can provide a considerable rate of seizure freedom. In addition, the neuropsychological outcomes of patients who underwent sSAH were slightly different among 6 studies. Therefore, large-scale case series or randomized controlled trials (RCTs) are needed to clarify the advantages and disadvantages of the sSAH.

中文翻译：

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颞叶内侧癫痫患者的颞下选择性杏仁核海马切除术：癫痫发作和神经心理学结果的系统评价

除了标准的前颞叶切除术（ATL）外，颞下选择性杏仁核海马切除术（sSAH）也是治疗难治性颞叶内侧癫痫（MTLE）的常用技术。我们进行了系统的文献回顾，以确定接受 sSAH 的 MTLE 患者的癫痫发作和神经心理学结果。我们使用与 sSAH、癫痫发作结果和神经心理学结果相关的医学主题词和关键词搜索了 PubMed 和 Embase。根据先验建立的纳入和排除标准筛选标题、摘要和全文。潜在论文由 3 位审稿人审阅，他们就最终纳入的论文达成共识。文献回顾确定了 208 篇摘要，共回顾了 29 篇全文文章。包含来自 4 个国家（3 大洲）的数据的 6 项研究符合我们的纳入标准。在 4 项研究中，sSAH 后 12 个月的无癫痫发作率为 59.1% 至 61.5%。四项研究表明，术后 24 个月的无癫痫发作率为 56% 至 82.6%。六项研究评估了 sSAH 后 MTLE 患者的神经心理变化，包括智力、语言记忆、非语言记忆、语言功能等。就神经心理学结果而言，这 6 项研究之间存在一些差异。总之，sSAH 可以提供相当高的无癫痫发作率。此外，接受 sSAH 的患者的神经心理学结果在 6 项研究中略有不同。所以，