In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was created bearing a single element transducer with diameter 50 mm and geometric focus 100 mm operating at 0.5 MHz. It included a set of tubes and a connector with multiple 0.4 mm openings, through which a suitable liquid is being circulated with a pump. The lesions were sealed with a thin homogenous layer of wax, preventing a liquid leakage. The system was tested successfully with FUS and a liquid leakage was achieved after FUS application. This set up is the first phantom model that has the potential to be utilized as a cost-effective solution for performing experiments for BBB disruption, without the need of using animal models.

中文翻译：

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血脑屏障破坏的聚焦超声模型

在本文中，开发了一种高强度聚焦超声 (FUS) 幻影模型，以用于血脑屏障 (BBB) 破坏实验。目标是创建一个代表在超声应用过程中 BBB 中断的幻影模型。创建了一个合适的实验装置，该装置带有一个直径为 50 毫米、几何焦点为 100 毫米的单晶换能器，工作频率为 0.5 MHz。它包括一组管子和一个带有多个 0.4 毫米开口的连接器，合适的液体通过这些开口用泵循环。病变用一层薄薄的均质蜡密封，防止液体泄漏。该系统通过 FUS 测试成功，并在 FUS 应用后实现了液体泄漏。