Histones carry information in the form of post-translational modifications (PTMs). For this information to be propagated through cell cycles, parental histones and their PTMs need to be maintained at the same genomic locations. Yet, during DNA replication, every nucleosome in the genome is disrupted to allow passage of the replisome. Recent data have identified histone chaperone activities that are intrinsic components of the replisome and implicate them in maintaining parental histones during DNA replication. We propose that structural and kinetic coordination between DNA replication and replisome-associated histone chaperone activities ensures positional inheritance of histones and their PTMs. When this coordination is perturbed, histones may instead be recycled to random genomic locations by alternative histone chaperones.

组蛋白携带翻译后修饰（PTM）形式的信息。为了使这些信息在细胞周期中传播，需要将亲本组蛋白及其PTM维持在相同的基因组位置。然而，在DNA复制过程中，基因组中的每个核小体都会被破坏，以允许复制体通过。最近的数据已经确定了组蛋白伴侣活性，它们是复制体的固有成分，并暗示它们在DNA复制过程中维持亲本组蛋白。我们建议DNA复制和复制体相关的组蛋白伴侣活性之间的结构和动力学协调确保组蛋白及其PTM的位置继承。当这种协调受到干扰时，组蛋白可以替代地由替代组蛋白伴侣回收到随机的基因组位置。