Keratoprosthesis (KPro) devices have the remarkable ability to restore vision in patients suffering from corneal blindness who are poor candidates for traditional penetrating keratoplasty. However, eyes with KPro can experience various complications, including the development of retroprosthetic membrane (RPM). RPMs reduce visual acuity in patients due to physical obstruction of the visual axis, but studies have shown that RPM can also lead to a variety of other consequences, from melting of the corneal carrier graft to precipitating retinal detachments. Histopathologic studies have shown that RPMs are composed of elements from both the recipient and donor. The presence of myofibroblasts in RPMs imparts them with contractile properties, which can contribute to their downstream complications, including angle closure, hypotony, and retinal detachment. At present, there are limited treatments to combat the growth of RPM. Future therapies could include anti-metabolites and targeted anti-inflammatory treatments, as well as device coatings or textured device surfaces that can hinder RPM proliferation. The long-term success of KPro depends on devising an effective solution for preventing RPM growth.

角膜塑形术（KPro）装置具有出色的恢复角膜盲患者视力的能力，这些患者不适合传统穿透性角膜移植术。但是，使用KPro的眼睛可能会遇到各种并发症，包括后修复膜（RPM）的发展。RPM会由于视轴的物理阻塞而降低患者的视敏度，但研究表明RPM还会导致其他各种后果，从角膜载体移植物融化到视网膜脱离。组织病理学研究表明，RPM由受者和供体两者组成。RPM中肌成纤维细胞的存在赋予它们收缩特性，这可能会导致其下游并发症，包括闭角，肌张力低下和视网膜脱离。目前，针对RPM增长的治疗方法有限。未来的疗法可能包括抗代谢物和靶向抗炎治疗，以及可能阻碍RPM扩散的器械涂层或有纹理的器械表面。KPro的长期成功取决于设计有效的解决方案来防止RPM增长。