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Sesquiterpenes from Echinacea purpurea and their anti-inflammatory activities
Phytochemistry ( IF 3.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.phytochem.2020.112503 Zhuo-Yang Cheng 1 , Xue Sun 1 , Ping Liu 2 , Bin Lin 3 , Ling-Zhi Li 1 , Guo-Dong Yao 1 , Xiao-Xiao Huang 4 , Shao-Jiang Song 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.phytochem.2020.112503 Zhuo-Yang Cheng 1 , Xue Sun 1 , Ping Liu 2 , Bin Lin 3 , Ling-Zhi Li 1 , Guo-Dong Yao 1 , Xiao-Xiao Huang 4 , Shao-Jiang Song 1
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Six unreported sesquiterpenes, purpureaterpenes A‒F, together with six known sesquiterpenes, were isolated and identified from the aerial part of Echinacea purpurea. Their chemical structures were established by detailed analyses of 1D and 2D NMR data. The relative configurations were assigned on the basis of their NOESY spectra and the calculated 13C NMR spectra. Their absolute configurations were determined by X-ray crystallographic analyses and optical rotation calculations. All the isolated compounds were tested for their anti-inflammatory effects against NO production in LPS-induced RAW246.7 macrophages. Among these compounds, purpureaterpene E was the most active (IC50 value 13.27 μM), even better than the positive control, minocycline (IC50 value 34.81 μM). Further investigation found that purpureaterpene E might exert anti-inflammatory property via the NF-κB signaling pathway.
中文翻译：
紫锥菊倍半萜类化合物及其抗炎活性
从紫锥菊的地上部分分离并鉴定出六种未报告的倍半萜，即紫锥菊 A-F，以及六种已知的倍半萜。它们的化学结构是通过对 1D 和 2D NMR 数据的详细分析确定的。相对构型是根据它们的 NOESY 光谱和计算的 13C NMR 光谱确定的。它们的绝对构型是通过 X 射线晶体学分析和旋光计算确定的。测试了所有分离的化合物对 LPS 诱导的 RAW246.7 巨噬细胞中 NO 产生的抗炎作用。在这些化合物中，purpureaterpene E 的活性最强（IC50 值为 13.27 μM），甚至优于阳性对照米诺环素（IC50 值为 34.81 μM）。
更新日期：2020-11-01
中文翻译：
紫锥菊倍半萜类化合物及其抗炎活性
从紫锥菊的地上部分分离并鉴定出六种未报告的倍半萜，即紫锥菊 A-F，以及六种已知的倍半萜。它们的化学结构是通过对 1D 和 2D NMR 数据的详细分析确定的。相对构型是根据它们的 NOESY 光谱和计算的 13C NMR 光谱确定的。它们的绝对构型是通过 X 射线晶体学分析和旋光计算确定的。测试了所有分离的化合物对 LPS 诱导的 RAW246.7 巨噬细胞中 NO 产生的抗炎作用。在这些化合物中，purpureaterpene E 的活性最强（IC50 值为 13.27 μM），甚至优于阳性对照米诺环素（IC50 值为 34.81 μM）。
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