In this issue of Neuron, through an elegant progression of computational and bio-informatic experiments centered on transcriptomic comparison of vulnerable and resistant neurons across species, Roussarie et al. (2020) predict and provide experimental support for specific genes and molecular pathways driving Alzheimer’s disease, including the splicing factor PTBP1.

中文翻译：

---

阿尔茨海默氏病中的选择性神经元脆弱性：现代圣杯。

在本期《神经元》中，通过计算和生物信息学实验的良好进展，重点是跨物种的易受攻击和抗性神经元的转录组学比较，Roussarie等。（2020）预测并为驱动阿尔茨海默氏病的特定基因和分子途径提供实验支持，包括剪接因子PTBP1。