Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T,NeuroImage

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Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T
NeuroImage ( IF 4.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.neuroimage.2020.117357
Julia P Slopsema ₁ , Antonietta Canna ₂ , Michelle Uchenik ₁ , Lauri J Lehto ₂ , Jordan Krieg ₁ , Lucius Wilmerding ₁ , Dee M Koski ₂ , Naoharu Kobayashi ₂ , Joan Dao ₁ , Madeline Blumenfeld ₁ , Pavel Filip ₃ , Hoon-Ki Min ₄ , Silvia Mangia ₂ , Matthew D Johnson ₅ , Shalom Michaeli ₂

Affiliation

Functional MRI (fMRI) has become an important tool for probing network-level effects of deep brain stimulation (DBS). Previous DBS-fMRI studies have shown that electrical stimulation of the ventrolateral (VL) thalamus can modulate sensorimotor cortices in a frequency and amplitude dependent manner. Here, we investigated, using a swine animal model, how the direction and orientation of the electric field, induced by VL-thalamus DBS, affects activity in the sensorimotor cortex. Adult swine underwent implantation of a novel 16-electrode (4 rows × 4 columns) directional DBS lead in the VL thalamus. A within-subject design was used to compare fMRI responses for (1) directional stimulation consisting of monopolar stimulation in four radial directions around the DBS lead, and (2) orientation-selective stimulation where an electric field dipole was rotated 0°−360° around a quadrangle of electrodes. Functional responses were quantified in the premotor, primary motor, and somatosensory cortices. High frequency electrical stimulation through leads implanted in the VL thalamus induced directional tuning in cortical response patterns to varying degrees depending on DBS lead position. Orientation-selective stimulation showed maximal functional response when the electric field was oriented approximately parallel to the DBS lead, which is consistent with known axonal orientations of the cortico-thalamocortical pathway. These results demonstrate that directional and orientation-selective stimulation paradigms in the VL thalamus can tune network-level modulation patterns in the sensorimotor cortex, which may have translational utility in improving functional outcomes of DBS therapy.

中文翻译：

通过 3T 功能 MRI 评估猪的定向选择性和定向深部脑刺激

功能性 MRI (fMRI) 已成为探索深部脑刺激 (DBS) 网络级效应的重要工具。以前的 DBS-fMRI 研究表明，腹外侧 (VL) 丘脑的电刺激可以以频率和幅度依赖的方式调节感觉运动皮层。在这里，我们使用猪动物模型研究了由 VL 丘脑 DBS 诱导的电场方向和方向如何影响感觉运动皮层的活动。成年猪在 VL 丘脑中植入了新型 16 电极（4 行 × 4 列）定向 DBS 导线。受试者内设计用于比较（1）定向刺激的 fMRI 响应，该刺激由 DBS 导线周围四个径向方向的单极刺激组成，(2) 方向选择性刺激，其中电场偶极子围绕四边形电极旋转 0°-360°。在前运动、初级运动和体感皮质中量化功能反应。根据 DBS 导线位置，通过植入 VL 丘脑的导线进行的高频电刺激会在不同程度上诱导皮层响应模式的定向调谐。当电场的方向大致平行于 DBS 导线时，定向选择性刺激显示出最大的功能反应，这与已知的皮质-丘脑皮质通路的轴突方向一致。这些结果表明，VL 丘脑中的定向和定向选择性刺激范式可以调节感觉运动皮层中的网络级调制模式，

更新日期：2021-01-01

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