Antibacterial coating is an important strategy preventing bacterial colonization and biofilm formation. One-step synthesis of nanocapsule-containing antibacterial coatings with controlled release of Ag⁺ ions was achieved in the current work by aerosol-assisted atmospheric pressure plasma deposition. The experimental parameters of deposition including the discharge power, silver nitrate concentration, aerosol flow rate, continuous and pulsed mode of operation were studied in order to analyze their effects on surface morphology and chemical composition of the coating. Formation of nanocapsules embedded in the polymeric coating was observed. A core-shell structure was found for nanocapsule with silver in the core and polymer in the shell. Antibacterial coatings on polyethylene terephthalate film were studied in terms of Ag⁺ ion release, antibacterial properties against Escherichia coli and Staphylococcus aureus, and cytotoxicity with murine fibroblasts. Two-phase release kinetics of Ag⁺ ions was observed as initially a short-term burst release followed by a long-term slow release. It was revealed that high antibacterial efficiency of the coatings deposited on polyethylene terephthalate films can be coupled with low cytotoxicity. These biocompatible antibacterial coatings are very promising in different fields including biological applications.

抗菌涂层是防止细菌定居和生物膜形成的重要策略。Ag ⁺控释的一步法合成含纳米胶囊的抗菌涂层在目前的工作中，通过气溶胶辅助的大气压等离子体沉积获得了离子。研究了沉积的实验参数，包括放电功率，硝酸银浓度，气溶胶流量，连续和脉冲操作模式，以分析它们对涂层表面形态和化学成分的影响。观察到包埋在聚合物涂层中的纳米胶囊的形成。发现了纳米胶囊的核-壳结构，其中核为银，壳为聚合物。从Ag ⁺离子释放，对大肠杆菌和金黄色葡萄球菌的抗菌性能方面研究了聚对苯二甲酸乙二醇酯薄膜上的抗菌涂层以及鼠成纤维细胞的细胞毒性。观察到Ag ⁺离子的两相释放动力学，最初是短期的突发释放，然后是长期的缓慢释放。揭示了沉积在聚对苯二甲酸乙二醇酯膜上的涂层的高抗菌效率可以与低细胞毒性结合。这些生物相容性抗菌涂料在包括生物应用在内的不同领域中非常有前途。