The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance. In this work, the “one stone two bird” agent of 1,10-phenanthroline (phen) is designed to disrupt the polymeric lanthanide MOFs (LnMOFs, [Ln(CHO₂)₃]_n, Ln = Tb, 1a; Eu, 1b, CHO₂ = formic acid) {[Ln(CHO₂)₄·(C₂H₈N)]_n, Ln = Y, 2a; Gd, 2b; Dy, 2c, C₂H₈N = dimethylamine}) into a soluble mononuclear species [Ln(phen)₂(NO₃)₃, Ln = Tb, 3a; Eu, 3b] as well as to provide an antenna for efficient photons absorption, resulting in an ultra-high luminescence quantum yield (QY, 90%) europium complex. The luminescence QY is among the highest record of monomeric (zero-dimensional) lanthanide complexes. Furthermore, mononuclear Tb³⁺ complex (3a) functions as a multiplex sensor towards both Fe²⁺ and cancer marker of 5-hydroxyindole-3-acetic acid (5-HIAA). Importantly, the limit of detection (LOD) for sensing 5-HIAA is an ultra-sensitive value of 1 × 10⁻⁸ mol/L, which is even lower than that necessary for the early diagnosis of carcinoid tumors. More interestingly, sensing results in simulated urine reveals that 3a has potential application for early diagnosis in the clinic.

开发一种高选择性和灵敏的探针来检测癌症标志物和金属离子是非常重要的。在这项工作中，1,10-菲咯啉 (phen) 的“一石二鸟”剂旨在破坏聚合镧系元素 MOFs (LnMOFs, [Ln(CHO ₂ ) ₃ ] _n , Ln = Tb, 1a ; Eu, 1b , CHO ₂  = 甲酸) {[Ln(CHO ₂ ) ₄ ·(C ₂ H ₈ N)] _n , Ln = Y, 2a ; Gd, 2b ; Dy, 2c , C ₂ H ₈N = 二甲胺}) 变成可溶的单核物质 [Ln(phen) ₂ (NO ₃ ) ₃ , Ln = Tb, 3a ; Eu, 3b ] 以及为有效光子吸收提供天线，从而产生超高发光量子产率 (QY, 90%) 铕络合物。发光 QY 是单体（零维）镧系元素配合物的最高记录之一。此外，单核 Tb ³⁺复合物 ( 3a ) 充当针对 Fe ²⁺和 5-羟基吲哚-3-乙酸 (5-HIAA) 的癌症标志物的多重传感器。重要的是，检测 5-HIAA 的检测限 (LOD) 是 1 × 10 ^-8的超灵敏值 mol/L，甚至低于类癌早期诊断所需的值。更有趣的是，模拟尿液中的传感结果表明3a在临床早期诊断方面具有潜在的应用价值。