The immune system protects the body against cancer by recognizing and eliminating neoplastic cells. Immune effector cells physically interact with cancer cells through a specialized membrane interface known as the immunological synapse. Such intimate interaction is necessary for immune cell activation and directional killing of target cells. A vast array of studies has established that actin cytoskeleton remodeling and membrane/vesicle trafficking play multiple and critical roles on the immune cell side of the immunological synapse. Increasing evidence supports that dynamic changes in actin cytoskeleton organization and vesicle trafficking also take place on the cancer cell side of the immunological synapse and that such changes are closely intertwined with evasion from immune destruction. In the present article, we review current knowledge of actin and vesicle dynamics in cancer cells during cytotoxic lymphocyte attack and tumor immune evasion.

免疫系统通过识别和消除肿瘤细胞来保护身体免受癌症侵害。免疫效应细胞通过称为免疫突触的特殊膜界面与癌细胞发生物理相互作用。这种密切的相互作用对于免疫细胞激活和目标细胞的定向杀伤是必要的。大量研究已经证实，肌动蛋白细胞骨架重塑和膜/囊泡运输在免疫突触的免疫细胞侧发挥着多重关键作用。越来越多的证据支持肌动蛋白细胞骨架组织和囊泡运输的动态变化也发生在免疫突触的癌细胞侧，并且这些变化与逃避免疫破坏密切相关。在本文中，