The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.,Experimental Gerontology

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The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.
Experimental Gerontology ( IF 3.3 ) Pub Date : 2020-09-09 , DOI: 10.1016/j.exger.2020.111090
Babak Hooshmand-Moghadam ₁ , Mozhgan Eskandari ₂ , Fateme Golestani ₂ , Saeed Rezae ₃ , Nahid Mahmoudi ₃ , Abbas Ali Gaeini ₄

Affiliation

Background

Regular physical activity has a positive effect on the prevention of cellular aging. The present study investigated the effect of 12-week resistance training (RT) on serum levels of Sirtuin-1 (SIRT1), Sirtuin-3 (SIRT3), Sirtuin-6 (SIRT6), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), and telomerase enzyme in elderly men.

Methods

For this purpose, 30 elderly men (age 66.23 ± 0.57 years) were randomly divided into two groups: resistance training group (RET, n = 15) and control group (CTR, n = 15). Participants in RET performed RT protocols with intensity of 60% one-repetition maximum (3×/week, 4 sets of the six exercise circuits). Body composition, physical functioning and, blood samples were assessed before (pre-test) and after (post-test) a 12-week intervention.

Results

The results showed that there was a significant increase in serum levels of SIRT1 (P = 0.001), SIRT3 (P = 0.001), SIRT6 (P = 0.02), PGC1-α (P = 0.001), and telomerase enzyme (P = 0.001) in RET. Also, we found a significant difference between the RET and CTR in serum levels of SIRT1 (P = 0.001), SIRT3 (P = 0.001), SIRT6 (P = 0.037), PGC1-α (P = 0.007), and telomerase enzyme (P = 0.001).

Conclusions

12-Week RT increased the levels of proteins associated with the biological aging process in elderly men. It seems that the RT may have beneficial effects on cellular senescence and also improved impaired mitochondrial protein and enzymatic functional induced aging.

中文翻译：

12周抵抗运动训练对老年男性血清细胞衰老过程参数水平的影响。

背景

定期进行体育锻炼对预防细胞衰老具有积极作用。本研究调查了12周抵抗训练（RT）对Sirtuin-1（SIRT1），Sirtuin-3（SIRT3），Sirtuin-6（SIRT6），过氧化物酶体增殖物激活的受体γ辅激活物1-alpha的血清水平的影响（PGC1-α）和端粒酶在老年男性中。

方法

为此，将30名老年男性（66.23±0.57岁）随机分为两组：抵抗力训练组（RET，n = 15）和对照组（CTR，n = 15）。参加RET的参与者进行的RT方案的最大重复强度为60％（3次/周，六个锻炼回路中的4组）。在12周的干预之前（测试前）和测试后（测试后）评估身体成分，身体机能和血液样本。

结果

结果显示，血清SIRT1（P = 0.001），SIRT3（P = 0.001），SIRT6（P = 0.02），PGC1-α（P = 0.001）和端粒酶（P = 0.001）的血清水平显着增加）。此外，我们发现RET和CTR在血清SIRT1（P = 0.001），SIRT3（P = 0.001），SIRT6（P = 0.037），PGC1-α（P = 0.007）和端粒酶（ P = 0.001）。