Abstract The graphene oxides (GO) were prepared by a ball milling process with potassium perchlorate as oxidizing agent and deionized water as milling medium. GO samples were synthesized at different processing times and compared with a sample prepared by the Hummer's method. The prepared graphene oxides have been studied by Fourier transform infrared (FTIR), Raman spectroscopies, powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). FTIR spectroscopy indicates presence of oxygen-bearing functional groups on the surface, Raman spectroscopy, XRD, SEM and TEM analysis confirm GO formation in ball milling. The sample processed for 12 h (GO 12 h) showed the highest yield of the product, presenting a suitable particle size (40 nm) for biomedical applications, especially in drug delivery systems. Ball milling can be considered as suitable method to obtain GO due to time processing, good quality of product and chemical components used.

中文翻译：

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球磨法从石墨合成氧化石墨烯

摘要 以高氯酸钾为氧化剂，去离子水为研磨介质，采用球磨法制备氧化石墨烯（GO）。GO 样品在不同的处理时间合成，并与 Hummer 方法制备的样品进行比较。通过傅里叶变换红外（FTIR）、拉曼光谱、粉末X射线衍射（XRD）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）对制备的氧化石墨烯进行了研究。FTIR 光谱表明表面存在含氧官能团，拉曼光谱、XRD、SEM 和 TEM 分析证实了球磨中 GO 的形成。处理 12 小时（GO 12 小时）的样品显示出最高的产品产率，为生物医学应用提供了合适的粒径（40 nm），尤其是在药物输送系统中。由于加工时间长、产品质量好和使用的化学成分，球磨被认为是获得 GO 的合适方法。