Introduction

Previous studies have shown contrasting results in determining efficacy of statins against amyloid beta accumulation. The aim of this study was to assess the impact of statin in AD. The protocol of the abstract was also registered in Prospero (CRD42018102557)

Method

We searched PubMed and Embase forrelevant preclinical studies. A meta-analysis of the statin's efficacy on amyloidosis and cognitive impairment was performed. Also, stratified analysis was performed on several covariates including the type of statinused, gender and age of rodents and duration of statin therapy, toaccount for the reported heterogeneity in the results obtained.

Result

17 studies including 22 comparisons, containing a sample size of 446rodents, participated in the meta-analysis of statin's effect on overall Aβ deposition. Although the effect of statin on overall Aβ deposition was found to be protective (p<0.00001) but as we categorized the efficacy ofstatin on different Aβ species (soluble and insoluble Aβ40/42) and Aβ plaque load, we found that significance in the protection decreased. A stratified meta-analysis demonstrated a significant role in the durationof statin supplements and rodent's age on the heterogeneity of the results. Statin administered to rodents for the longest duration (> 6months) and younger rodents (less than 6 months of age) demonstrated significant efficacy of statin on Aβ deposition.

Conclusion

Statin showed reduction in Aβ level but stratified analysis revealed that this effect of statin was dependent on rodent’s age and duration of the treatment.

中文翻译：

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他汀类药物对阿尔茨海默病啮齿动物模型淀粉样变性的影响：来自临床前荟萃分析的证据。

介绍

先前的研究表明，在确定他汀类药物对抗淀粉样蛋白 β 积累的功效时，结果截然不同。本研究的目的是评估他汀类药物对 AD 的影响。摘要的协议也在Prospero注册（CRD42018102557）

方法

我们在 PubMed 和 Embase 中搜索了相关的临床前研究。对他汀类药物对淀粉样变性和认知障碍的疗效进行了荟萃分析。此外，对几个协变量进行了分层分析，包括他汀类药物的类型、啮齿动物的性别和年龄以及他汀类药物治疗的持续时间，以解释所报告的结果中的异质性。

结果

17 项研究（包括 22 项比较，包含 446 只啮齿动物的样本量）参与了他汀类药物对整体 Aβ 沉积影响的荟萃分析。尽管发现他汀类药物对整体 Aβ 沉积的影响具有保护性（p<0.00001），但当我们对他汀类药物对不同 Aβ 种类（可溶性和不溶性 Aβ40/42）和 Aβ 斑块负荷的功效进行分类时，我们发现在保护性方面的重要性减少了。分层荟萃分析表明，他汀类药物补充剂的持续时间和啮齿动物的年龄对结果的异质性具有重要作用。对啮齿动物给药最长持续时间（> 6 个月）和年轻啮齿动物（小于 6 个月）的他汀类药物显示他汀类药物对 Aβ 沉积的显着疗效。

结论

他汀类药物显示 Aβ 水平降低，但分层分析显示他汀类药物的这种作用取决于啮齿动物的年龄和治疗持续时间。