An advanced molecularly imprinted electrochemical sensor with high sensitivity and selectivity for the detection of Human immunoglobulin G (IgG) was successfully constructed. With acrylamide imprinting systems, surface imprinting on the nanoparticles CuFe₂O₄ targeted at IgG was employed to prepare molecularly imprinted polymer, which served as recognition element for the electrochemical sensor. Furthermore, the sensor harnessed a molybdenum disulfide (MoS₂)@nitrogen doped graphene quantum dots (N-GQDs) with ionic liquid (IL) nanocomposite for signal amplification. Under optimized experimental conditions, the sensor shortened the response time to less than 8 min, and the response was linear at the IgG concentration of 0.1–50 ng·mL⁻¹ with a low detection limit of 0.02 ng·mL⁻¹ (S/N = 3). Our findings suggested that, the sensor exhibited high detectability and long-time stability. The satisfactory results of human serum sample analysis showed that the developed IgG sensor had promising potential clinical applications in detecting IgG content.

成功构建了一种用于检测人免疫球蛋白 G (IgG) 的具有高灵敏度和选择性的先进分子印迹电化学传感器。利用丙烯酰胺印迹系统，在靶向IgG的纳米颗粒CuFe ₂ O ₄上进行表面印迹制备分子印迹聚合物，作为电化学传感器的识别元件。_{此外，该传感器利用二}硫化钼 (MoS2 )@氮掺杂石墨烯量子点 (N-GQD) 和离子液体 (IL) 纳米复合材料来放大信号。在优化的实验条件下，传感器将响应时间缩短到不到 8 分钟，并且在 IgG 浓度为 0.1–50 ng·mL ^{−1时响应呈线性}具有 0.02 ng·mL ⁻¹ (S/N = 3) 的低检测限。我们的研究结果表明，该传感器表现出高检测性和长期稳定性。人血清样品分析的满意结果表明，所开发的 IgG 传感器在检测 IgG 含量方面具有广阔的临床应用前景。