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Bioactive Diarylheptanoids from Alpinia coriandriodora.
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-09-09 , DOI: 10.1007/s13659-020-00264-y
Xiao-Li Cheng 1, 2 , Han-Xiang Li 1, 3 , Juan Chen 1, 3 , Ping Wu 1, 2, 3 , Jing-Hua Xue 1, 3 , Zhong-Yu Zhou 1, 2, 3 , Nia-He Xia 1, 2, 3 , Xiao-Yi Wei 1, 2, 3
Affiliation  

Eight new diarylheptanoids, coriandralpinins A–H (18), were isolated from the rhizomes of Alpinia coriandriodora, an edible plant of the ginger family. Their structures, including the absolute configurations, were established by extensive spectroscopic analysis and ECD calculations. Compounds 18 have a 1,5-O-bridged diarylheptanoid structure featuring polyoxygenated aryl units. When evaluated for intracellular antioxidant activity using t-BHP stressed RAW264.7 macrophages, all these compounds scavenged reactive oxygen species (ROS) in a concentration-dependent manner. Compounds 3 and 5 also showed inhibitory activity against NO release in LPS-induced RAW 264.7 cells. Six known flavonols, 7,4′-di-O-methylkaempferol, 7-O-methylquercetin, 7,4′-di-O-methylquercetin, 7,3′,4′-tri-O- methylquercetin, kaempferol 3-O-β-d-(6-O-α-l-rhamnopyranosyl)glucopyranoside, and 3-O-β-d-glucopyranuronosylquercetin were also isolated and characterized from the rhizomes.



中文翻译:

来自高良姜的生物活性二芳基庚烷。

从姜科植物的食用植物高积的根茎中分离出了八种新的二芳基庚烷类化合物,即香菜松素A–H(18)。通过广泛的光谱分析和ECD计算,确定了它们的结构,包括绝对构型。化合物18具有1,5- O桥联的二芳基庚烷结构,具有多氧化芳基单元。当使用t- BHP胁迫的RAW264.7巨噬细胞评估细胞内抗氧化活性时,所有这些化合物均以浓度依赖的方式清除了活性氧(ROS)。化合物35在LPS诱导的RAW 264.7细胞中也显示出对NO释放的抑制活性。六种已知黄酮醇,7,4'-二- ø -methylkaempferol,7- ö -methylquercetin,7,4'-二- ø -methylquercetin,7,3',4'-三ø - methylquercetin,山柰酚3- ö - β - d - (6- ø - α --rhamnopyranosyl)D-吡喃葡萄糖苷,和3- ö - β - d -glucopyranuronosylquercetin也分离并从根茎表征。

更新日期:2020-09-10
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