Abstract

Two new Cd(II) containing coordination polymers, namely {[Cd(Dib)(1,4-Ndc)] · H₂O}_n (I, Dib = 1,4-di(1H-imidazol-1-yl)butane, 1,4-H₂Ndc = naphthalene-1,4-dicarboxylic acid) and [Cd(2,2′-Dsb)-(Dpe)-(DMF)(H₂O)] (II, 2,2′-H₂Dsb = 2,2′-disulfanediyldibenzoic acid, Dpe = (E)-1,2-di(pyridin-4-yl)ethene), have been successfully prepared under the hydrothermal or solvothermal conditions by using the carboxylic acid and N-donor linkers with different functional groups as the co-ligands. Furthermore, the CCK-8 assay was performed to detect the inhibitory effect of these two synthetic complexes on the NCI-H292 lung cancer cell line. The mechanism of the complexes anti-cancer activity was explored with Annexin V-FITC/PI apoptosis detection and western blot assay.

中文翻译：

---

两种杂配Cd（II）配位聚合物：晶体结构和抗肺癌活性评估

摘要

两种含有配位聚合物的新Cd（II），即{[Cd（Dib）（1,4-Ndc）]·H ₂ O} _n（I，Dib = 1,4-di（1 H-咪唑-1-基）丁烷，1,4-H ₂ Ndc =萘-1,4-二羧酸）和[Cd（2,2'-Dsb）-（Dpe）-（DMF）（H ₂ O）]（II，2， 2'-H ₂ Dsb = 2,2'-二硫代二基二苯甲酸，Dpe =（E）-1,2-二（吡啶-4-基）乙烯）是通过使用具有不同官能团的羧酸和N-供体连接体作为共配体在水热或溶剂热条件下成功制备的。此外，进行CCK-8测定以检测这两种合成复合物对NCI-H292肺癌细胞系的抑制作用。通过膜联蛋白V-FITC / PI凋亡检测和western blot分析探讨了复合物抗癌活性的机制。