Abstract

Comparative results of the study of the biological distribution of ⁶⁸Ga incorporated in NODA aminoglucose in mice organs and tissues with the experimental model of malignant tumor and aseptic inflammation are presented. It is revealed that pathological conditions have no significant effect on the ⁶⁸Ga-NODA aminoglucose behavior after intravenous administration. The dynamics of activity accumulation and excretion in most organs and tissues had no significant differences. The level of activity accumulation in tumor and muscular tissue with inflammation at 1 h after injection of ⁶⁸Ga-NODA-aminoglucose exceeded the same values in other organs and tissues, except kidneys. The obtained results show the promising application of 68Ga-NODA- aminoglucose for imaging pathological lesions by positron emission tomography.

中文翻译：

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NODA氨基葡萄糖中掺入68镓在具有各种病理过程的实验动物中的行为

摘要

提出了与恶性肿瘤和无菌性炎症实验模型相比，将NODA氨基葡萄糖中掺入的⁶⁸ Ga的生物分布在小鼠器官和组织中的研究结果的比较结果。揭示了静脉内给药后病理状况对⁶⁸ Ga-NODA氨基葡萄糖行为没有显着影响。大多数器官和组织中活动积累和排泄的动力学没有显着差异。注射⁶⁸小时后1小时，肿瘤和肌肉组织中有炎症的活动积累水平Ga-NODA-氨基葡萄糖在肾脏以外的其他器官和组织中均超过相同值。获得的结果表明68Ga-NODA-氨基葡萄糖在正电子发射断层显像成像病理病变中具有广阔的应用前景。