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Cascade cyclization versus chemoselective reduction: a solvent-controlled product divergence
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-09-08 , DOI: 10.1039/d0qo00876a
Farnaz Jafarpour 1, 2, 3, 4, 5 , Saideh Rajai-Daryasarei 1, 2, 3, 4, 5 , Mohammad Hossein Gohari 1, 2, 3, 4, 5
Affiliation  

A simple and efficient strategy for the assembly of polysubstituted thiophenes and the chemoselective reduction of α,β-unsaturated ketones via the reaction of enones with elemental sulfur and by a simple switching of the reaction solvent is described. Mechanistic studies revealed that both the reactions proceeded via radical pathways, and two hydrogen atoms came from H2O in the reduction course.

中文翻译:

级联环化与化学选择性还原:溶剂控制的产物差异

描述了通过烯酮与元素硫的反应以及通过简单地切换反应溶剂来组装多取代的噻吩和化学选择性还原α,β-不饱和酮的简单有效的策略。机制研究揭示,进行两种反应经由自由基途径,和两个氢原子选自H来到2中的O减少过程。
更新日期:2020-09-24
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