Cascade cyclization versus chemoselective reduction: a solvent-controlled product divergence,Organic Chemistry Frontiers

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Cascade cyclization versus chemoselective reduction: a solvent-controlled product divergence
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-09-08 , DOI: 10.1039/d0qo00876a
Farnaz Jafarpour _{1,

2,

3,

4,

5} , Saideh Rajai-Daryasarei _{1,

2,

3,

4,

5} , Mohammad Hossein Gohari _{1,

2,

3,

4,

5}

Affiliation

A simple and efficient strategy for the assembly of polysubstituted thiophenes and the chemoselective reduction of α,β-unsaturated ketones via the reaction of enones with elemental sulfur and by a simple switching of the reaction solvent is described. Mechanistic studies revealed that both the reactions proceeded via radical pathways, and two hydrogen atoms came from H₂O in the reduction course.

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