Transient imine directing groups for the C-H functionalisation of aldehydes, ketones and amines: an update 2018-2020.,Organic & Biomolecular Chemistry

当前位置： X-MOL 学术 › Org. Biomol. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Transient imine directing groups for the C-H functionalisation of aldehydes, ketones and amines: an update 2018-2020.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-09-08 , DOI: 10.1039/d0ob01587c
Joe I Higham ₁ , James A Bull ₁

Affiliation

The use of pre-installed directing groups has become a popular and powerful strategy to control site selectivity in transition metal catalysed C–H functionalisation reactions. However, the necessity for directing group installation and removal reduces the efficiency of a directed C–H functionalisation method. To overcome this limitation, taking inspiration from organocatalytic methodologies, the use of transient directing groups has arisen. These methods allow for a transient ligand to be used, potentially in catalytic quantities, without the need for discrete installation or removal steps, enabling the discovery of more efficient, and mechanistically intriguing, dual catalytic methods. This review summarises recent developments in this fast moving field covering >70 new methodologies, highlighting new directing group designs and advances in mechanistic understanding. It covers progress since 2018, providing an update to our previous review of the field.

中文翻译：

用于醛、酮和胺的 CH 官能化的瞬时亚胺导向基团：2018-2020 年更新。

使用预先安装的导向基团已成为控制过渡金属催化 C-H 官能化反应中位点选择性的流行且强大的策略。然而，定向基团安装和移除的必要性降低了定向 C-H 功能化方法的效率。为了克服这一限制，受到有机催化方法的启发，出现了瞬态导向基团的使用。这些方法允许使用瞬态配体，可能以催化量使用，而不需要离散的安装或移除步骤，从而能够发现更有效、机械上有趣的双催化方法。这篇综述总结了这个快速发展领域的最新发展，涵盖 >70 新方法，强调了新的导向组设计和机械理解方面的进步。它涵盖了 2018 年以来的进展，提供了我们之前对该领域的回顾的更新。

更新日期：2020-09-30

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11