Background:The impact of concurrent osteoarthritis on mobility and mortality in individuals with Parkinson’s disease is unknown. Objective:We sought to understand to what extent osteoarthritis severity influenced mobility across time and how osteoarthritis severity could affect mortality in individuals with Parkinson’s disease. Methods:In a retrospective observational longitudinal study, data from the Parkinson’s Foundation Quality Improvement Initiative was analyzed. We included 2,274 persons with Parkinson’s disease. The main outcomes were the effects of osteoarthritis severity on functional mobility and mortality. The Timed Up and Go test measured functional mobility performance. Mortality was measured as the osteoarthritis group effect on survival time in years. Results:More individuals with symptomatic osteoarthritis reported at least monthly falls compared to the other groups (14.5% vs. 7.2% without reported osteoarthritis and 8.4% asymptomatic/minimal osteoarthritis, p = 0.0004). The symptomatic group contained significantly more individuals with low functional mobility (TUG≥12 seconds) at baseline (51.5% vs. 29.0% and 36.1%, p < 0.0001). The odds of having low functional mobility for individuals with symptomatic osteoarthritis was 1.63 times compared to those without reported osteoarthritis (p < 0.0004); and was 1.57 times compared to those with asymptomatic/minimal osteoarthritis (p = 0.0026) after controlling pre-specified covariates. Similar results hold at the time of follow-up while changes in functional mobility were not significant across groups, suggesting that osteoarthritis likely does not accelerate the changes in functional mobility across time. Coexisting symptomatic osteoarthritis and Parkinson’s disease seem to additively increase the risk of mortality (p = 0.007). Conclusion:Our results highlight the impact and potential additive effects of symptomatic osteoarthritis in persons with Parkinson’s disease.

中文翻译：

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并存的骨关节炎和帕金森病：来自帕金森基金会成果项目的数据。

背景：并发骨关节炎对帕金森病患者活动能力和死亡率的影响尚不清楚。目的：我们试图了解骨关节炎的严重程度在多大程度上影响随时间推移的活动能力，以及骨关节炎的严重程度如何影响帕金森病患者的死亡率。方法：在一项回顾性观察纵向研究中，分析了帕金森基金会质量改进计划的数据。我们纳入了 2,274 名帕金森病患者。主要结果是骨关节炎严重程度对功能活动性和死亡率的影响。Timed Up and Go 测试测量了功能移动性能。死亡率被测量为骨关节炎组对存活时间的影响（以年为单位）。结果：与其他组相比，更多的有症状骨关节炎患者报告至少每月跌倒一次（14.5% 与 7.2% 没有报告骨关节炎，8.4% 无症状/轻微骨关节炎，p = 0.0004）。有症状组在基线时包含显着更多的低功能活动性（TUG≥12 秒）个体（51.5% 对 29.0% 和 36.1%，p < 0.0001）。与没有报告骨关节炎的人相比，有症状的骨关节炎患者功能活动度低的几率是 1.63 倍（p < 0.0004）；在控制了预先指定的协变量后，与无症状/轻微骨关节炎（p = 0.0026）的患者相比是 1.57 倍。类似的结果在随访时也成立，而功能流动性的变化在各组之间并不显着，表明骨关节炎可能不会加速功能活动性随时间的变化。症状性骨关节炎和帕金森病并存似乎会增加死亡风险（p = 0.007）。结论：我们的研究结果强调了症状性骨关节炎对帕金森病患者的影响和潜在的累加效应。