Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry.,Environmental Health Perspectives

当前位置： X-MOL 学术 › Environ. Health Perspect. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry.
Environmental Health Perspectives ( IF 10.1 ) Pub Date : 2020-9-8 , DOI: 10.1289/ehp6803
Julia A Bauer ₁ , Katrina L Devick ₂ , Jennifer F Bobb ₃ , Brent A Coull ₄ , David Bellinger _{5,

6,

7} , Chiara Benedetti ₈ , Giuseppa Cagna ₈ , Chiara Fedrighi ₈ , Stefano Guazzetti ₉ , Manuela Oppini ₈ , Donatella Placidi ₈ , Thomas F Webster ₁ , Roberta F White _{1,

10} , Qiong Yang ₁₁ , Silvia Zoni ₈ , Robert O Wright ₁₂ , Donald R Smith ₁₃ , Roberto G Lucchini _{8,

12} , Birgit Claus Henn ₁

Affiliation

Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Division of Biomedical Statistics and Informatics, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Departments of Neurology and Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA.
Departments of Neurology and Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Department of Medical-Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, Italy.
Azienda Unità Sanitaria Locale Reggio Emilia, Reggio Emilia, Italy.
Department of Neurology, Boston University Medical School, Boston, Massachusetts, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.

Abstract

Background:

Research on the health effects of chemical mixtures has focused mainly on early life rather than adolescence, a potentially important developmental life stage.

Objectives:

We examined associations of a metal mixture with general cognition in a cross-sectional study of adolescents residing near ferromanganese industry, a source of airborne metals emissions.

Methods:

We measured manganese (Mn), lead (Pb), copper (Cu), and chromium (Cr) in hair, blood, urine, nails, and saliva from 635 Italian adolescents 10–14 years of age. Full-scale, verbal, and performance intelligence quotient (FSIQ, VIQ, PIQ) scores were assessed using the Wechsler Intelligence Scale for Children-III. Multivariable linear regression and Bayesian kernel machine regression (BKMR) were used to estimate associations of the metal mixture with IQ. In secondary analyses, we used BKMR’s hierarchical variable selection option to inform biomarker selection for Mn, Cu, and Cr.

Results:

Median metal concentrations were as follows: hair Mn, $0.08 micrograms per gram$ ; hair Cu, $9.6 micrograms per gram$ ; hair Cr, $0.05 micrograms per gram$ ; and blood Pb, $1.3 micrograms per deciliter$ . Adjusted models revealed an inverted U-shaped association between hair Cu and VIQ, consistent with Cu as an essential nutrient that is neurotoxic in excess. At low levels of hair Cu (10th percentile, $5.4 micrograms per gram$ ), higher concentrations (90th percentiles) of the mixture of Mn, Pb, and Cr ( $0.3 micrograms per gram$ , $2.6 micrograms per deciliter$ , and $0.1 micrograms per gram$ , respectively) were associated with a 2.9 (95% CI: $negative 5.2$ , $negative 0.5$ )–point decrease in VIQ score, compared with median concentrations of the mixture. There was suggestive evidence of interaction between Mn and Cu. In secondary analyses, saliva Mn, hair Cu, and saliva Cr were selected as the biomarkers most strongly associated with VIQ score.

Discussion:

Higher adolescent levels of Mn, Pb, and Cr were associated with lower IQ scores, especially at low Cu levels. Findings also support further investigation into Cu as both beneficial and toxic for neurobehavioral outcomes. https://doi.org/10.1289/EHP6803

中文翻译：

多种生物标志物测量的金属混合物与智商的关联：来自居住在铁合金工业附近的意大利青少年的证据。

抽象的

背景：

关于化学混合物对健康影响的研究主要集中在生命早期，而不是青春期，青春期是一个潜在的重要的生命发育阶段。

目标：

我们对居住在铁锰工业附近的青少年进行了一项横断面研究，研究了金属混合物与一般认知的关联，铁锰工业是空气中金属排放的一个来源。

方法：

我们测量了 635 名 10-14 岁意大利青少年的头发、血液、尿液、指甲和唾液中的锰 (Mn)、铅 (Pb)、铜 (Cu) 和铬 (Cr)。使用韦氏儿童智力量表 III 评估全面智商、语言智商和表现智商（FSIQ、VIQ、PIQ）分数。使用多变量线性回归和贝叶斯核机器回归（BKMR）来估计金属混合物与智商的关联。在二次分析中，我们使用 BKMR 的分层变量选择选项来通知 Mn、Cu 和 Cr 的生物标志物选择。

结果：

金属浓度中位数如下：头发 Mn、 $0.08 micrograms per gram$ ;头发铜, $9.6 micrograms per gram$ ;头发铬， $0.05 micrograms per gram$ ;和血铅， $1.3 micrograms per deciliter$ 。调整后的模型显示，头发中的铜和 VIQ 之间存在倒 U 形关联，这与铜作为一种必需营养素，过量会产生神经毒性一致。头发铜含量低（第 10 个百分点， $5.4 micrograms per gram$ ），Mn、Pb 和 Cr 混合物的浓度较高（第 90 个百分位数）（ $0.3 micrograms per gram$ , $2.6 micrograms per deciliter$ ，和 $0.1 micrograms per gram$ 分别）与 2.9 相关（95% CI： $negative 5.2$ , $negative 0.5$ )–与混合物的中位浓度相比，VIQ 分数下降。有暗示性证据表明锰和铜之间存在相互作用。在二次分析中，唾液 Mn、头发 Cu 和唾液 Cr 被选为与 VIQ 评分最密切相关的生物标志物。

讨论：

更新日期：2020-09-08

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11