Pegaharines A–G (1–6), six novel β-carboline alkaloids representing three types of skeleton, were isolated from the seeds of Peganum harmala. Compound 1 is a peculiar β-carboline alkaloid characterized by the unprecedented carbon skeleton of an azepine–indole system. Compounds 3–6 represent the first examples of heterodimers constructed from rare tetracyclic β-carboline and classic tricyclic β-carboline alkaloids. Compounds 1 and 2 were characterized by X-ray crystallography. Compound 4 exhibited strong antiviral activity against HSV-2, with an IC₅₀ value of 2.12 ± 0.14 μM.

中文翻译：

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山核桃种子中的 β-咔啉生物碱及其抗 HSV-2 病毒活性。

Pegaharines A-G（1 - 6），六表示三种类型的骨架的新颖的β咔啉生物碱，从种子中分离骆驼蓬。化合物1是一种特殊的 β-咔啉生物碱，其特征是前所未有的氮杂-吲哚系统碳骨架。化合物3 - 6表示选自稀土四环β咔啉和经典三环β咔啉生物碱构成的异二聚体的第一实施例。化合物1和2通过 X 射线晶体学表征。化合物4对HSV-2表现出很强的抗病毒活性，IC ₅₀值为2.12 ± 0.14 μM。