Nowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) is a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener. Its protective effect on I/R injury has been confirmed in many organs such as the heart and brain. However, the mechanism of its protective effect has not been fully elucidated. MicroRNAs (miRNAs) are widely involved in pathologies of heart disease. In this study, we found that miR-10a expression was highly upregulated in the myocardial I/R groups, and DZ treatment significantly reduced the expression of miR-10a. More importantly, we found that DZ treatment can moderate ERS via regulation of the miR-10a/IRE1 pathway in the I/R and H/R models, thereby protecting myocardial H/R injury.

中文翻译：

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二氮嗪可通过调节miR-10a / IRE1途径来调节ERS，从而预防心肌缺血/再灌注损伤。

如今，再灌注仍然是缺血性心脏病的最有效治疗方法。但是，心脏再灌注治疗会导致再灌注损伤，这可能是由于再灌注过程中的内质网应激（ERS）引起的。二氮嗪（DZ）是一种高度选择性的线粒体三磷酸腺苷敏感性钾通道开放剂。它对I / R损伤的保护作用已在心脏和大脑等许多器官中得到证实。但是，其保护作用的机理尚未完全阐明。MicroRNA（miRNA）广泛涉及心脏病的病理过程。在这项研究中，我们发现心肌I / R组中miR-10a的表达高度上调，DZ处理显着降低了miR-10a的表达。更重要的是，