Catalytic Enantioselective Functionalizations of C-H Bonds by Chiral Iridium Complexes.,Chemical Reviews

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Catalytic Enantioselective Functionalizations of C-H Bonds by Chiral Iridium Complexes.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-09-08 , DOI: 10.1021/acs.chemrev.0c00559
Łukasz Woźniak ₁ , Jin-Fay Tan ₁ , Qui-Hien Nguyen ₁ , Adrien Madron du Vigné ₁ , Vitalii Smal ₁ , Yi-Xuan Cao ₁ , Nicolai Cramer ₁

Affiliation

The development of catalytic enantioselective transformations, enabling the construction of complex molecular scaffolds from simple precursors, has been a long-standing challenge in organic synthesis. Recent achievements in transition-metal catalyzed enantioselective functionalizations of carbon–hydrogen (C–H) bonds represent a promising pathway toward this goal. Over the last two decades, iridium catalysis has evolved as a valuable tool enabling the stereocontrolled synthesis of chiral molecules via C–H activation. The development of iridium-based systems with various chiral ligand classes, as well as studies of their reaction mechanisms, has resulted in dynamic progress in this area. This review aims to present a comprehensive picture of the enantioselective functionalizations of C–H bonds by chiral iridium complexes with emphasis on the mechanisms of the C–H activation step.

中文翻译：

CH手性铱配合物对CH键的催化对映选择性官能化。

催化对映选择性转化的发展，使得能够由简单的前体构建复杂的分子支架，一直是有机合成中的长期挑战。过渡金属催化的碳氢（C–H）键对映选择性官能化的最新进展为实现该目标提供了有希望的途径。在过去的二十年中，铱催化已经发展成为一种有价值的工具，能够通过C–H激活来立体控制手性分子的合成。具有各种手性配体类别的基于铱的系统的开发以及它们的反应机理的研究已导致该领域的动态发展。

更新日期：2020-09-23

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