Abstract Allyl pyridyl ethers are important intermediates in organic synthesis, which could be accessed by Williamson or SNAr-type etherification. While Williamson etherification has been well studied, the SNAr-type reaction remains less explored. In this paper, a series of allyl pyridyl ethers were synthesized via transition metal-free SNAr-type etherification with different allyl alcohols in good yields. The poor-yielding etherification for cinnamyl alcohol was finally optimized to 82% yield with a molecular sieve as the additive. Graphical Abstract

中文翻译：

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与烯丙醇的无过渡金属 SNAr 型醚化：烯丙基吡啶基醚的合成

摘要 烯丙基吡啶基醚是有机合成中重要的中间体，可通过Williamson 或SNAr 型醚化反应获得。虽然威廉姆森醚化已经得到很好的研究，但对 SNAr 型反应的探索仍然较少。在本文中，通过无过渡金属的SNAr型醚化与不同的烯丙醇以良好的收率合成了一系列烯丙基吡啶基醚。肉桂醇的低收率醚化最终以分子筛作为添加剂优化到 82% 的收率。图形概要