Abstract

In chronic wounds area, there is an abnormally low amount of extracellular matrix, which urges for the extra new biomimetic material to promote proper wound healing. Because of their unique characteristics such as inherent bioactivity, biocompatibility, biodegradability and mimicking the natural ECM, natural polymer and their derivative are widely explored as the functional active wound dressing and carrier of antimicrobial agents or growth factors to enhance wound healing. In this review, the wound healing application of polysaccharides, proteins and their derivatives as the active wound dressing and as the carriers of pharmaceutical agents was briefly reviewed.

摘要

在慢性伤口区域，细胞外基质的含量异常低，这需要额外的新型仿生材料来促进适当的伤口愈合。由于其固有的生物活性、生物相容性、生物降解性和模仿天然 ECM 的独特特性，天然聚合物及其衍生物被广泛探索作为功能性活性伤口敷料和抗菌剂或生长因子的载体，以促进伤口愈合。本综述简要回顾了多糖、蛋白质及其衍生物作为活性伤口敷料和药物载体的伤口愈合应用。