ABSTRACT

By utilising the mixed-ligand approach, a novel coordination polymer based on Zn(II) ions as nodes have been synthesised by the Zn(NO₃)₂ · 6H₂O reacting with 1,4-H₂NDC in the presence of a second N-donor ligand L, and its chemical formula is {[Zn(L)_1.5(1,4-NDC)]·H₂O}_n (1, 1,4-H₂NDC = 1,4-naphthalenedicarboxylic acid and L = N,N′-di(4-pyridyl)suberoamide). The as-synthesised complex 1 reveals outstanding water stability and it could be utilised as a platform of the multi-responsive recyclable luminescent sensor for the Al³⁺ and Fe³⁺ in water. The compound was synthesised in this research for the tuberculosis treatment. The biological function of the compound was assessed, and its detailed mechanism was explored. The Mycobacterium bacterial numbers in lung tissue was determined with spread plate method. In addition to this, the real-time reverse transcription-polymerase chain reaction (RT-PCR) method was conducted to determine the inhibition of compound against the ropA expression in Mycobacterium.

摘要

采用混合配体的方法，Zn(NO ₃ ) ₂  · 6H ₂ O 与 1,4-H ₂ NDC反应合成了一种以 Zn(II) 离子为节点的新型配位聚合物。第二N-供体配体L，其化学式为{[Zn(L) _1.5 (1,4-NDC)]·H ₂ O} _n ( 1 , 1,4-H ₂ NDC = 1,4-萘二甲酸L =  N,N'-二(4-吡啶基)辛二酰胺)。合成后的配合物1具有出色的水稳定性，可用作 Al ³⁺和 Fe的多响应可回收发光传感器的平台³⁺在水中。本研究合成了该化合物，用于治疗肺结核。对该化合物的生物学功能进行了评估，并探讨了其详细机制。用扩散板法测定肺组织中的分枝杆菌数量。除此之外，进行实时逆转录聚合酶链反应（RT-PCR）方法以确定化合物对分枝杆菌中ropA表达的抑制作用。