Abstract Thermo- and pH-responsive polyrotaxane (PR)-based triblock copolymers were synthesized by atom transfer radical polymerization (ATRP) of N-isopropylacrylamide initiated with polypsudorotaxanes which were presynthesized from bromine end-capped poly(ethylene glycol)/poly(propylene glycol) with cyclodextrins in the presence of CuBr/HMDETA under near physiological conditions. The triblock copolymers were characterized by 1H NMR, FT-IR, GPC (gel permeation chromatography) analyses. Thermo- and pH-responsive behavior evaluated by UV–Vis spectroscopies, DLS (dynamic light scattering), and TEM (transmission electron microscopy) images showed that its lower critical solution temperature (LCST) was slightly increased with increasing pH values due to hydroxyl groups of cyclodextrin depending on pH values.

中文翻译：

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基于环糊精的ATRP双刺激响应三嵌段聚轮烷的合成与表征

摘要 通过 N-异丙基丙烯酰胺的原子转移自由基聚合 (ATRP) 合成了热响应和 pH 响应的聚轮烷 (PR) 基三嵌段共聚物。 ) 在接近生理条件下，在 CuBr/HMDETA 存在下使用环糊精。三嵌段共聚物通过1H NMR、FT-IR、GPC(凝胶渗透色谱)分析表征。通过紫外-可见光谱、DLS（动态光散射）和 TEM（透射电子显微镜）图像评估的热和 pH 响应行为表明，由于羟基的存在，其下临界溶解温度 (LCST) 随 pH 值的增加而略微增加环糊精的浓度取决于 pH 值。