The division and cell wall (dcw) cluster is a highly conserved region of the bacterial genome consisting of genes that encode several cell division and cell wall synthesis factors, including the central division protein FtsZ. The region immediately downstream of ftsZ encodes the ylm genes and is conserved across diverse lineages of Gram-positive bacteria and Cyanobacteria. In some organisms, this region remains part of the dcw cluster, but in others, it appears as an independent operon. A well-studied protein coded from this region is the positive FtsZ regulator SepF (YlmF), which anchors FtsZ to the membrane. Recent developments have shed light on the importance of SepF in a range of species. Additionally, new studies are highlighting the importance of the other conserved genes in this neighborhood. In this minireview, we aim to bring together the current research linking the ylm region to cell division and highlight further questions surrounding these conserved genes.

中文翻译：

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ylm不仅有（Z锚）环！

分裂和细胞壁（dcw）簇是细菌基因组中高度保守的区域，由编码几种细胞分裂和细胞壁合成因子（包括中央分裂蛋白FtsZ）的基因组成。ftsZ紧接下游的区域编码ylm基因，在革兰氏阳性细菌和蓝细菌的不同谱系中都保守。在某些生物中，该区域仍然是DCW的一部分集群，但在其他集群中，它看起来像一个独立的操纵子。从该区域编码的一种经过充分研究的蛋白是正FtsZ调节剂SepF（YlmF），它将FtsZ锚定在膜上。最近的发展揭示了SepF在一系列物种中的重要性。此外，新的研究突出了该区域其他保守基因的重要性。在这个minireview，我们的目标是汇集了目前的研究链接YLM区域细胞分裂，并强调围绕这些保守基因进一步的问题。