The mechanisms underlying hypertension are multi-faceted and incompletely understood. New evidence suggests that the G protein-coupled estrogen receptor 1 (GPER1) mediates protective actions within the cardiovascular and renal systems. This minireview focuses on recent advancements in our understanding of the vascular, renal, and cardiac GPER1-mediated mechanisms that influence blood pressure regulation. We emphasize clinical and basic evidence that suggests GPER1 as a novel target to aid therapeutic strategies for hypertension. Furthermore, we discuss current controversies and challenges facing GPER1-related research.

中文翻译：

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G 蛋白偶联雌激素受体 1 作为血压的新型调节剂。

高血压的潜在机制是多方面的，并且尚未完全了解。新证据表明 G 蛋白偶联雌激素受体 1 (GPER1) 介导心血管和肾脏系统内的保护作用。这篇小综述重点关注我们对影响血压调节的血管、肾脏和心脏 GPER1 介导的机制的理解的最新进展。我们强调临床和基础证据表明 GPER1 是辅助高血压治疗策略的新靶点。此外，我们讨论了当前 GPER1 相关研究面临的争议和挑战。