The influence of Ni2+ and other ions on the trigonal structure of DNA,Biopolymers

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The influence of Ni2+ and other ions on the trigonal structure of DNA
Biopolymers ( IF 3.2 ) Pub Date : 2020-09-08 , DOI: 10.1002/bip.23397
Francisco J Acosta-Reyes ₁ , Mireia Pagan ₁ , Elsa Fonfría-Subirós ₁ , Núria Saperas ₁ , Juan A Subirana ₁ , J Lourdes Campos ₁

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We present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form well-defined DNA nanostructures. We also compare our structure with other dodecamers which present unique features and also crystallize in trigonal unit cells, strongly influenced by the counterions associated with DNA. In all cases, the DNA duplexes form parallel pseudo-helical columns in the crystal, similar to DNA-protamine and native DNA fibers.

中文翻译：

Ni2+等离子对DNA三角结构的影响

我们提出了在 Ni2+ 离子存在下获得的 DNA 十二聚体的新结构。DNA 在相邻分子之间形成镍鸟嘌呤交联。我们的结果表明，足够剂量的 Ni2+ 可能有助于形成明确的 DNA 纳米结构。我们还将我们的结构与其他十二聚体进行了比较，这些十二聚体呈现出独特的特征，并且也在三角晶胞中结晶，受到与 DNA 相关的反离子的强烈影响。在所有情况下，DNA 双链体在晶体中形成平行的假螺旋柱，类似于 DNA 鱼精蛋白和天然 DNA 纤维。

更新日期：2020-09-08

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