Palladium‐Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes,Advanced Synthesis & Catalysis

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Palladium‐Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-09-07 , DOI: 10.1002/adsc.202000537
Chenchen Wang ₁ , Wenyu Zhao ₁ , Xianqing Wu ₁ , Jingping Qu ₁ , Yifeng Chen ₁

Affiliation

A palladium‐catalyzed domino spiro‐cyclization of carbamoyl chlorides with alkynes and benzynes, involving intramolecular C−H activation to afford valuable oxindole scaffolds bearing spiro quaternary stereocenters, has been developed. This one‐step synthesis of spirooxindole is both step‐ and atom‐economic, proceeding with high regioselectivity in moderate to excellent yields.

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