The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis.,STEM CELLS

当前位置： X-MOL 学术 › STEM CELLS › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis.
STEM CELLS ( IF 4.0 ) Pub Date : 2020-09-07 , DOI: 10.1002/stem.3273
M Pilar Pedro ₁ , Katherine Lund ₁ , Ramiro Iglesias-Bartolome ₁

Affiliation

Continuous integration of signals from the micro‐ and macro‐environment is necessary for somatic stem cells to adapt to changing conditions, maintain tissue homeostasis, and activate repair mechanisms. G‐protein coupled receptors (GPCRs) facilitate this integration by binding to numerous hormones, metabolites, and inflammatory mediators, influencing a diverse network of pathways that regulate stem cell fate. This adaptive mechanism is particularly relevant for tissues that are exposed to environmental assault, like skin. The skin is maintained by a set of basal keratinocyte stem and progenitor cells located in the hair follicle and interfollicular epidermis, and several GPCRs and their signaling partners serve as makers and regulators of epidermal stem cell activity. GPCRs utilize heterotrimeric G protein dependent and independent pathways to translate extracellular signals into intracellular molecular cascades that dictate the activation of keratinocyte proliferative and differentiation networks, including Hedgehog GLI, Hippo YAP1 and WNT/β‐catenin, ultimately regulating stem cell identity. Dysregulation of GPCR signaling underlines numerous skin inflammatory diseases and cancer, with smoothened‐driven basal cell carcinoma being a main example of a GPCR‐associated cancer. In this review, we discuss the impact of GPCRs and their signaling partners in skin keratinocyte biology, particularly in the regulation of the epidermal stem cell compartment.

中文翻译：

GPCR 信号在表皮干细胞命运和皮肤稳态调节中的作用。

来自微观和宏观环境的信号的持续整合对于成体干细胞适应不断变化的条件、维持组织稳态和激活修复机制是必要的。 G蛋白偶联受体（GPCR）通过与多种激素、代谢物和炎症介质结合来促进这种整合，影响调节干细胞命运的多种途径网络。这种适应性机制与暴露于环境攻击的组织（例如皮肤）特别相关。皮肤由位于毛囊和毛囊间表皮中的一组基底角质形成细胞干细胞和祖细胞维持，并且一些 GPCR 及其信号传导伴侣充当表皮干细胞活性的制造者和调节者。 GPCR 利用异三聚体 G 蛋白依赖性和独立途径将细胞外信号转化为细胞内分子级联，从而决定角质形成细胞增殖和分化网络的激活，包括 Hedgehog GLI、Hippo YAP1 和 WNT/β-catenin，最终调节干细胞身份。 GPCR 信号传导失调强调了许多皮肤炎症性疾病和癌症，平滑驱动的基底细胞癌是 GPCR 相关癌症的一个主要例子。在这篇综述中，我们讨论了 GPCR 及其信号伙伴在皮肤角质形成细胞生物学中的影响，特别是在表皮干细胞区室的调节中。

更新日期：2020-09-07

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11