The drug delivery performances of pH‐responsive magnetic hydrogels (MHs) composed of tragacanth gum (TG), poly(acrylic acid) (PAA), and Fe₃O₄ nanoparticles (NPs) were investigated in terms of physicochemical as well as biological features. The fabricated drug delivery systems (DDSs) were analyzed using Fourier transform infrared spectroscopy, X‐ray diffraction, vibrating sample magnetometer, scanning electron microscopy, and transmission electron microscopy. The synthesized MHs were loaded with doxorubicin hydrochloride (Dox) as a universal model anti‐cancer drug. The MHs showed excellent Dox loading and encapsulation efficiencies, mainly due to strong hydrogen bonding and electrostatic interaction between the drug and polymeric matrix, as well as porous micro‐structures of the fabricated MHs. The drug‐loaded MHs showed negligible drug release values in physiological condition. In contrast, in cancerous condition (pH 5.0), both MHs exhibited highest drug release values that qualified them as “smart” DDSs. The cytocompatibilities of the MHs as well as the cytotoxicity of the Dox‐loaded MHs were investigated against human epidermoid‐like carcinoma (Hela) cells through MTT assay. In addition, hyperthermia therapy induced by Fe₃O₄ NPs was applied to locally raise temperature inside the Hela cells at 45 ± 3°C to promote cell death. As a result, the Dox‐loaded MHs can be considered as potential DDSs for chemo/hyperthermia therapy of solid tumors.

中文翻译：

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基于黄ga胶的pH响应磁性水凝胶，用于“智能”实体瘤的化学/高热治疗

由黄aga胶（TG），聚丙烯酸（PAA）和Fe ₃ O ₄组成的pH响应磁性水凝胶（MHs）的药物传递性能从物理化学和生物学特性方面研究了纳米颗粒（NPs）。使用傅立叶变换红外光谱仪，X射线衍射仪，振动样品磁力计，扫描电子显微镜和透射电子显微镜对装配好的药物递送系统（DDS）进行了分析。合成的MH载有盐酸阿霉素（Dox）作为通用模型抗癌药。MH表现出出色的Dox装载和封装效率，这主要是由于药物与聚合物基质之间强大的氢键结合和静电相互作用以及所制造MH的多孔微结构所致。在生理条件下，载药的MHs的药物释放值可忽略不计。相反，在癌症状态（pH 5.0）下，两种MH均显示出最高的药物释放值，使它们成为“智能” DDS。通过MTT试验研究了MH对人表皮样癌细胞（Hela）的细胞相容性以及载有Dox的MH的细胞毒性。另外，铁引起的热疗_使用3 O ₄ NP在Hela细胞内部以45±3°C的温度局部升高温度，以促进细胞死亡。结果，载有Dox的MH可被视为对实体瘤进行化学/高热治疗的潜在DDS。