Pharmaceutical technologies with potential application to insecticide discovery†,Pest Management Science

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Pharmaceutical technologies with potential application to insecticide discovery†
Pest Management Science ( IF 3.8 ) Pub Date : 2020-09-08 , DOI: 10.1002/ps.6075
Keith D Wing ₁

Affiliation

Novel neuroactive insecticides are discovered/registered differently, have a lower value in use, and exert their physiological actions in manners distinct from neuroactive pharmaceuticals, but there are clear similarities in their biochemical modes of action. Insecticides are generally discovered using whole pest insect screens, and this eases difficulties in ‘translational science’ from laboratory to field, as opposed to pharmaceutical translation from biochemical or cell-based targets to animal models to human clinical trials to registered drug. This paper examines recent trends in pharmaceutical science and identifies some technologies which may represent complementary approaches to insecticide discovery screening and mode of action determination beyond the sound processes in common practice today. Examples will be drawn from nanoparticle delivery of neuroactives, unique ligand–polymer conjugates, proposed advances in insect cell culture following from pharmaceutical cell biology, and laboratory or organ-on-a-chip approaches. It is hoped that these concepts will stimulate novel thinking which may enable discovery of efficacious new neuroactive insecticides. © 2020 Society of Chemical Industry

中文翻译：

可用于发现杀虫剂的制药技术†

新型神经活性杀虫剂的发现/注册方式不同，使用价值较低，并且以不同于神经活性药物的方式发挥其生理作用，但它们的生化作用方式有明显的相似之处。杀虫剂通常是使用完整的害虫筛选来发现的，这与从生物化学或基于细胞的目标到动物模型到人体临床试验再到注册药物的药物转化不同，这减轻了从实验室到现场的“转化科学”的困难。本文研究了制药科学的最新趋势，并确定了一些技术，这些技术可能代表了除当今常见做法之外的健全过程之外的杀虫剂发现筛选和作用方式确定的补充方法。示例将包括神经活性物质的纳米颗粒递送、独特的配体-聚合物偶联物、在药物细胞生物学以及实验室或芯片上的器官方法之后昆虫细胞培养方面的拟议进展。希望这些概念能够激发新思维，从而发现有效的新型神经活性杀虫剂。© 2020 化学工业协会

更新日期：2020-09-08

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