Overt speech feasibility using continuous functional magnetic resonance imaging: Isolation of areas involved in phonology and prosody.,Journal of Neuroscience Research

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Overt speech feasibility using continuous functional magnetic resonance imaging: Isolation of areas involved in phonology and prosody.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-09-07 , DOI: 10.1002/jnr.24723
David Hassanein Berro _{1,

2,

3} , Jean-Michel Lemée _{3,

4} , Louis-Marie Leiber ₅ , Evelyne Emery _{1,

6} , Philippe Menei _{3,

4} , Aram Ter Minassian _{7,

8}

Affiliation

To avoid motion artifacts, almost all speech‐related functional magnetic resonance imagings (fMRIs) are performed covertly to detect language activations. This method may be difficult to execute, especially by patients with brain tumors, and does not allow the identification of phonological areas. Here, we aimed to evaluate overt task feasibility. Thirty‐three volunteers participated in this study. They performed two functional sessions of covert and overt generation of a short sentence semantically linked with a word. Three main contrasts were performed: Covert and Overt for the isolation of language‐activated areas, and Overt > Covert for the isolation of the motor cortical activation of speech. fMRI data preprocessing was performed with and without unwarping, and with and without regression of movement parameters as confounding variables. All types of results were compared to each other. For the Overt contrast, Dice coefficients showed strong overlap between each pair of types of results: 0.98 for the pair with and without unwarping, and 0.9 for the pair with and without movement parameter regression. The Overt > Covert contrast allowed isolation of motor laryngeal activations with high statistical reliability and revealed the right‐lateralized temporal activity related to acoustic feedback. Overt speaking during magnetic resonance imaging induced few artifacts and did not significantly affect the results, allowing the identification of areas involved in primary motor control and prosodic regulation of speech. Unwarping and motion artifact regression in the postprocessing step, seem to not be necessary. Changes in lateralization of cortical activity by overt speech shall be explored before using these tasks for presurgical mapping.

中文翻译：

使用连续功能磁共振成像的公开语音可行性：音韵学和韵律相关区域的隔离。

为了避免运动伪影，几乎所有与语音相关的功能磁共振成像 (fMRI) 都是秘密进行的，以检测语言激活。这种方法可能难以执行，特别是对于患有脑肿瘤的患者，并且不允许识别语音区域。在这里，我们旨在评估公开的任务可行性。33 名志愿者参加了这项研究。他们执行了两个功能会话，即隐蔽和公开生成一个与单词语义相关的短句。进行了三个主要对比：用于隔离语言激活区域的 Covert 和 Overt，以及用于隔离语音运动皮层激活的 Overt > Covert。fMRI 数据预处理是在有和没有反变形的情况下进行的，并且有和没有作为混杂变量的运动参数的回归。将所有类型的结果相互比较。对于明显对比，Dice 系数在每对类型的结果之间显示出强烈的重叠：0.98 对有和没有 unwarping 的对，0.9 对有和没有运动参数回归的对。Overt > Covert 对比允许以高统计可靠性隔离运动喉部活动，并揭示与声反馈相关的右侧化时间活动。在磁共振成像期间公开讲话几乎不会引起伪影，并且不会显着影响结果，从而可以识别涉及初级运动控制和语音韵律调节的区域。后处理步骤中的反变形和运动伪影回归似乎没有必要。

更新日期：2020-10-19

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